First pregnancy and live birth in Turkey following frozen-thawed ovarian tissue transplantation in a patient with acute lymphoblastic leukemia who underwent cord blood transplantation

Purpose To report the first live birth after frozen-thawed ovarian transplantation in Turkey and the second case for an acute lymphoblastic leukemia (ALL) survivor in the world. Methods A 19-year-old patient underwent ovarian tissue cryopreservation (OTC) before cord blood transplantation in 2010. S...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2020-08, Vol.37 (8), p.2033-2043
Main Authors: Sonmezer, Murat, Ozkavukcu, Sinan, Sukur, Yavuz Emre, Kankaya, Duygu, Arslan, Onder
Format: Article
Language:English
Subjects:
17β-Estradiol
Acute lymphoblastic leukemia
Adult
Biopsy
Bone marrow transplantation
Cord blood
Cord Blood Stem Cell Transplantation
Cryopreservation
Embryo Transfer
Embryos
Female
Fertility
Fertility Preservation
Fertility Preservation - methods
Follicle-stimulating hormone
Follicles
Gynecology
Human Genetics
Humans
Immunohistochemistry
Karyotypes
Leukemia
Live Birth
Lymphatic leukemia
Medicine
Medicine & Public Health
Menopause
Menstruation
Ovarian Follicle - transplantation
Ovaries
Ovary - transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery
Pregnancy
Pregnancy, Multiple
Remission
Reproductive Medicine
Translocation, Genetic - genetics
Turkey - epidemiology
Ultrasound
Young Adult
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Summary:Purpose To report the first live birth after frozen-thawed ovarian transplantation in Turkey and the second case for an acute lymphoblastic leukemia (ALL) survivor in the world. Methods A 19-year-old patient underwent ovarian tissue cryopreservation (OTC) before cord blood transplantation in 2010. She was diagnosed as ALL with a bone marrow biopsy revealing 90% blast ALL-L2 type, and karyotype analyses indicated reciprocal translocation at t(9;22)(q34;q11). The patient received the Berlin-Frankfurt-Munster (BFM) protocol, and complete remission was achieved before fertility preservation. Serum AMH level was measured as 1.5 ng/ml, and 12 antral follicles were counted on ultrasound. She was informed about fertility preservation options and decided to proceed with OTC, with her signed consent before cord blood transplantation in April 2011. Ovarian tissue transplantation (OTT) was performed in 2017 when the patient was menopausal with serum FSH levels > 100 IU/ml and estradiol
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-020-01850-2