Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs

The purpose of this study was to clarify the distribution of marbofloxacin (MBFX) within the bronchoalveolar region of pigs. Four clinically healthy pigs were intramuscularly injected with a single dose of MBFX (2 mg/kg). Samples of plasma and bronchoalveolar lavage fluid (BALF) were obtained for ea...

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Published in:Journal of Veterinary Medical Science 2020, Vol.82(8), pp.1080-1083
Main Authors: IJIRI, Moe, ISHIKAWA, Shingo, JIBIKI, Yoshinori, MIYAZAWA, Masataka, SENOKUCHI, Akane, HOBO, Seiji
Format: Article
Language:English
Subjects:
Alveolar Epithelial Cells - metabolism
Alveoli
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
bronchoalveolar lavage fluid
Bronchoalveolar Lavage Fluid - chemistry
Bronchus
distribution
Female
Fluoroquinolones - administration & dosage
Fluoroquinolones - blood
Fluoroquinolones - pharmacokinetics
Hogs
Injections, Intramuscular - veterinary
Internal Medicine
marbofloxacin
pig
Swine - metabolism
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cited_by cdi_FETCH-LOGICAL-c732t-59aca8d8024f66d4ab4c5be1fa16d1276445b6da70cb490d928a5072d4ce2a403
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container_issue 8
container_start_page 1080
container_title Journal of Veterinary Medical Science
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creator IJIRI, Moe
ISHIKAWA, Shingo
JIBIKI, Yoshinori
MIYAZAWA, Masataka
SENOKUCHI, Akane
HOBO, Seiji
description The purpose of this study was to clarify the distribution of marbofloxacin (MBFX) within the bronchoalveolar region of pigs. Four clinically healthy pigs were intramuscularly injected with a single dose of MBFX (2 mg/kg). Samples of plasma and bronchoalveolar lavage fluid (BALF) were obtained for each pig at 0 (before administration), 3, 8 and 24 hr after administration of MBFX. As a result, the MBFX concentrations in pulmonary epithelial lining fluid (ELF) and in alveolar cells showed a similar pattern of concentrations during the experimental period. The MBFX concentrations both in ELF and alveolar cells were higher than in plasma. These results suggest that intramuscularly injected MBFX was well distributed in the bronchoalveolar region.
doi_str_mv 10.1292/jvms.20-0239
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subjects Alveolar Epithelial Cells - metabolism
Alveoli
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
bronchoalveolar lavage fluid
Bronchoalveolar Lavage Fluid - chemistry
Bronchus
distribution
Female
Fluoroquinolones - administration & dosage
Fluoroquinolones - blood
Fluoroquinolones - pharmacokinetics
Hogs
Injections, Intramuscular - veterinary
Internal Medicine
marbofloxacin
pig
Swine - metabolism
title Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs
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