Advanced biomaterials for cancer immunotherapy

Immunotherapy, as a powerful strategy for cancer treatment, has achieved tremendous efficacy in clinical trials. Despite these advancements, there is much to do in terms of enhancing therapeutic benefits and decreasing the side effects of cancer immunotherapy. Advanced nanobiomaterials, including li...

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Bibliographic Details
Published in:Acta pharmacologica Sinica 2020-07, Vol.41 (7), p.911-927
Main Authors: Yang, Fan, Shi, Kun, Jia, Yan-peng, Hao, Ying, Peng, Jin-rong, Qian, Zhi-yong
Format: Article
Language:English
Subjects:
Antitumor activity
Biocompatible Materials - chemistry
Biocompatible Materials - therapeutic use
Biomaterials
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer immunotherapy
Clinical trials
Humans
Immune response
Immunology
Immunomodulation
Immunosuppressive agents
Immunotherapy
Internal Medicine
Liposomes
Medical Microbiology
Nanomaterials
Nanoparticles
Nanoparticles - chemistry
Neoplasms - immunology
Neoplasms - therapy
Pharmacology/Toxicology
Polymers
Review
Review Article
Silica
Vaccine
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Summary:Immunotherapy, as a powerful strategy for cancer treatment, has achieved tremendous efficacy in clinical trials. Despite these advancements, there is much to do in terms of enhancing therapeutic benefits and decreasing the side effects of cancer immunotherapy. Advanced nanobiomaterials, including liposomes, polymers, and silica, play a vital role in the codelivery of drugs and immunomodulators. These nanobiomaterial-based delivery systems could effectively promote antitumor immune responses and simultaneously reduce toxic adverse effects. Furthermore, nanobiomaterials may also combine with each other or with traditional drugs via different mechanisms, thus giving rise to more accurate and efficient tumor treatment. Here, an overview of the latest advancement in these nanobiomaterials used for cancer immunotherapy is given, describing outstanding systems, including lipid-based nanoparticles, polymer-based scaffolds or micelles, inorganic nanosystems, and others.
ISSN:1671-4083
1745-7254
DOI:10.1038/s41401-020-0372-z