Prevalence of Asymptomatic and/or Low-Density Malaria Infection among High-Risk Groups in Peninsular Malaysia

Asymptomatic and/or low-density malaria infection has been acknowledged as an obstacle to achieving a malaria-free country. This study aimed to determine the prevalence of asymptomatic and/or low-density malaria infection in previously reported malarious localities using nested PCR in four states, n...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2020-09, Vol.103 (3), p.1107-1110
Main Authors: Noordin, Naqib Rafieqin, Lee, Phone Youth, Mohd Bukhari, Fatma Diyana, Fong, Mun Yik, Abdul Hamid, Mohd Hafizi, Jelip, Jenarun, Mudin, Rose Nani, Lau, Yee Ling
Format: Article
Language:English
Subjects:
Adolescent
Adult
Asymptomatic
Asymptomatic Infections - epidemiology
Female
Humans
Infections
Malaria
Malaria - epidemiology
Malaria - parasitology
Malaria, Vivax - epidemiology
Malaria, Vivax - parasitology
Malaysia - epidemiology
Male
Middle Aged
Plasmodium - genetics
Plasmodium - isolation & purification
Plasmodium knowlesi - genetics
Plasmodium knowlesi - isolation & purification
Plasmodium ovale - genetics
Plasmodium ovale - isolation & purification
Plasmodium vivax - genetics
Plasmodium vivax - isolation & purification
Polymerase Chain Reaction
Prevalence
Young Adult
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Summary:Asymptomatic and/or low-density malaria infection has been acknowledged as an obstacle to achieving a malaria-free country. This study aimed to determine the prevalence of asymptomatic and/or low-density malaria infection in previously reported malarious localities using nested PCR in four states, namely, Johor, Pahang, Kelantan, and Selangor, between June 2019 and January 2020. Blood samples ( = 585) were collected and were extracted using a QIAamp blood kit. The DNA was concentrated and subjected to nested PCR. Thin and thick blood smears were examined as well. Of the 585 samples collected, 19 were positive: 10 for , eight for , and one for . Asymptomatic and/or low-density malaria infection is a threat to malaria elimination initiatives. Eliminating countries should develop guidance policy on the importance of low-density malaria infection which includes detection and treatment policy.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.20-0268