COVID-19 and Comorbid Hypertension: Is ACE2 the Culprit?

[...]the association between ACE2 levels and COVID-19 infection are still uncertain. Besides the ACE2 level, the ACE2 structural variation and gene polymorphism should also be noted. Some structural variations of human ACE2 have been identified, characterized by a low binding affinity with S-protein...

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Bibliographic Details
Published in:Prehospital and Disaster Medicine 2020-12, Vol.35 (6), p.700-701
Main Authors: Zhang, Ting, Zhong, Sen, Cao, Wenzhai
Format: Article
Language:English
Subjects:
Angiotensin Receptor Antagonists - adverse effects
Angiotensin-Converting Enzyme 2 - genetics
Angiotensin-Converting Enzyme Inhibitors - adverse effects
Animals
Cardiovascular disease
Comorbidity
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - enzymology
Diabetes
Disease Susceptibility
Enzymes
Gene expression
Humans
Hypertension
Hypertension - complications
Hypertension - drug therapy
Hypotheses
Infections
Letter to the Editor
Proteins
Risk Factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
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Summary:[...]the association between ACE2 levels and COVID-19 infection are still uncertain. Besides the ACE2 level, the ACE2 structural variation and gene polymorphism should also be noted. Some structural variations of human ACE2 have been identified, characterized by a low binding affinity with S-proteins with potential protective implications. [...]various ACE2 gene polymorphisms may link to SARS-CoV-2 infections from viral entrance to replication. Ziegler found that there are ACE2 and TMPRSS2 co-expression cells, a rare subset of epithelial cells, in respiratory tissues.Reference Ziegler, Allon and Nyquist10 Whether ACE2 and TMPRSS2 are needed on the same cell or some proteases could activate SARS-CoV-2 S-protein to invade ACE2 single-positive cells is still unclear. [...]as for the susceptibility of COVID-19 infections with hypertension patients, attention should also be paid to ACE2 and TMPRSS2 expression in the lung tissue and the interaction between them in order to make a comprehensive judgment.
ISSN:1049-023X
1945-1938
DOI:10.1017/S1049023X20001090