Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19

Coagulation dysfunction and inflammatory status were compared between diabetic and non-diabetic COVID-19 patients. The standardized mean difference (SMD) and its 95% confidence interval (CI) was computed for the difference of inflammatory and hypercoagulability markers. The levels of serum ferritin...

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Bibliographic Details
Published in:Journal of thrombosis and thrombolysis 2021-05, Vol.51 (4), p.941-946
Main Authors: Varikasuvu, Seshadri Reddy, Varshney, Saurabh, Dutt, Naveen
Format: Article
Language:English
Subjects:
Biomarkers - blood
Blood Coagulation
C-reactive protein
Cardiology
Coagulation
Comorbidity
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - epidemiology
COVID-19 - immunology
Diabetes
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - epidemiology
Diabetes Mellitus - immunology
Disease Susceptibility
Ferritin
Fibrinogen
Hematology
Humans
Inflammation
Inflammation - blood
Inflammation - etiology
Interleukin 6
Medicine
Medicine & Public Health
Research Letter
SARS-CoV-2
Thrombophilia - blood
Thrombophilia - etiology
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Summary:Coagulation dysfunction and inflammatory status were compared between diabetic and non-diabetic COVID-19 patients. The standardized mean difference (SMD) and its 95% confidence interval (CI) was computed for the difference of inflammatory and hypercoagulability markers. The levels of serum ferritin (standardized mean difference-SMD: 0.47, CI 0.17–0.77, p = 0.002), C-reactive protein (SMD = 0.53, CI 0.20–0.86, p = 0.002), interleukin-6 (SMD = 0.31, CI 0.09–0.52, p = 0.005), fibrinogen (SMD = 0.31, CI 0.09–0.54, p = 0.007) and D-dimers (SMD = 0.54, CI 0.16–0.91, p = 0.005) were significantly higher in diabetic COVID-19 cases as compared to non-diabetic COVID-19 patients, suggesting more susceptibility of diabetic COVID-19 patients to coagulation dysfunction and inflammatory storm.
ISSN:0929-5305
1573-742X
DOI:10.1007/s11239-020-02270-w