Serum Small Proline-Rich Protein 2A (SPRR2A) Is a Noninvasive Biomarker in Gastric Cancer

Objective. Since early diagnosis is very important for treating gastric cancer (GC), we aimed to detect serum small proline-rich protein2A (SPRR2A) to verify its diagnostic value for GC patients. Methods. Serum samples were collected from 200 patients with GC, 100 patients with gastritis, 40 patient...

Full description

Saved in:
Bibliographic Details
Published in:Disease markers 2020, Vol.2020 (2020), p.1-8
Main Authors: Wang, Xianjun, Yu, Daojun, Chen, Yueming, Wei, Shumei, Xu, Xiaoming, Dong, Xueyan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Antigens
Biomarkers
Biomarkers, Tumor - blood
Carcinoembryonic antigen
Carcinoembryonic Antigen - blood
Case-Control Studies
Cell adhesion & migration
Chemotherapy
Colon
Colon cancer
Colorectal cancer
Colorectal carcinoma
Cornified Envelope Proline-Rich Proteins - blood
Correlation analysis
Diagnostic systems
Early Detection of Cancer
Endoscopy
Enzyme-linked immunosorbent assay
Female
Gastric cancer
Gastritis
Gene Expression Regulation, Neoplastic
Guanylate cyclase
Hospitals
Humans
Laboratories
Lymph nodes
Lymphatic Metastasis
Male
Males
Medical prognosis
Medicine
Metastases
Middle Aged
Neoplasm Staging
Patients
Proline
Radiation therapy
Rectum
Sensitivity
Sensitivity and Specificity
Software
Stomach Neoplasms - blood
Stomach Neoplasms - diagnosis
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Surgery
Up-Regulation
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. Since early diagnosis is very important for treating gastric cancer (GC), we aimed to detect serum small proline-rich protein2A (SPRR2A) to verify its diagnostic value for GC patients. Methods. Serum samples were collected from 200 patients with GC, 100 patients with gastritis, 40 patients with rectal cancer (RC), 50 patients with colon cancer (CC), and 100 healthy controls. An enzyme-linked immunosorbent assay (ELISA) detection kit was applied to measure serum SPRR2A concentration. The correlations between serum SPRR2A and carcinoembryonic antigen (CEA), clinical pathological parameters of GC, and receiver operating characteristic (ROC) curve were also analyzed. Results. The median serum SPRR2A concentration in GC patients was significantly higher than those in healthy controls and gastritis or colorectal cancer patients (P
ISSN:0278-0240
1875-8630
DOI:10.1155/2020/8493796