Carbonic Anhydrase 4 serves as a Clinicopathological Biomarker for Outcomes and Immune Infiltration in Renal Cell Carcinoma, Lower Grade Glioma, Lung Adenocarcinoma and Uveal Melanoma

Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between and different cancers are indistinct. Differential mRNA expression of among different cancers and corresponding normal tissues wa...

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Bibliographic Details
Published in:Journal of Cancer 2020-01, Vol.11 (20), p.6101-6113
Main Authors: Xu, Yue, Xu, Wen-Hao, Shi, Shen-Nan, Yang, Xiao-Long, Ren, Ya-Ru, Zhuang, Xin-Yu, Qu, Yuan-Yuan, Zhang, Hai-Liang, Zhang, Xiao-Feng
Format: Article
Language:English
Subjects:
Biomarkers
Carbon dioxide
Correlation analysis
Cytokines
Cytotoxicity
Gene expression
Genomes
Glioma
Homeostasis
Kidney cancer
Lung cancer
Medical prognosis
Melanoma
Prostate
Proteins
Research Paper
Skin cancer
Software
Tumors
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Summary:Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between and different cancers are indistinct. Differential mRNA expression of among different cancers and corresponding normal tissues was compared based on datasets on the Cancer Genome Atlas (TCGA) platforms. Then, survival analysis was performed using Tumor-immune system interactionsplatform and TCGA cohort on the basis of distinct comparison expression of in five kinds of tumors. In addition, molecular penal analysis and functional annotations of -related genes was elaborated. The correlation between mRNA expression and tumor immune microenvironment were analyzed in detail. Compared with adjacent normal tissues, mRNA expressions were found significantly lower in various tumors. Moreover, decreased expression of was significantly related to worse overall survival (OS) and progression-free survival (PFS) in kidney renal clear cell carcinoma (KIRC), brain lower grade glioma (LGG), lung adenocarcinoma (LUAD) and uveal melanoma (UVM), and worse OS of prostate adenocarcinoma (PRAD) (
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.46902