Dronedarone-Mediated Acute Hepatic and Renal Toxicity

Dronedarone, a drug similar in chemical properties to amiodarone, was designed to have similar pharmacodynamic properties as amiodarone with fewer side effects. Although there have been cases of chronic liver enzyme elevation with dronedarone, only a few cases have been reported in literature where...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-08, Vol.12 (8)
Main Authors: Khan, Zarak H, Mukhtar, Kashif, Ahmed, Munis M, Zaidi, Syeda Ramsha, Abd Algayoum, Randa
Format: Article
Language:English
Subjects:
Gastroenterology
Nephrology
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Summary:Dronedarone, a drug similar in chemical properties to amiodarone, was designed to have similar pharmacodynamic properties as amiodarone with fewer side effects. Although there have been cases of chronic liver enzyme elevation with dronedarone, only a few cases have been reported in literature where it has led to rapid onset of liver failure. We present the case of an 86-year-old male who developed acute liver failure concomitantly with acute kidney failure after he was started on dronedarone therapy.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.9611