Long-term PERG monitoring of untreated and treated glaucoma suspects

Purpose To investigate long-term structural and functional progression of untreated and treated glaucoma suspects (UGS and TGS). Methods Retrospective analysis of serial steady-state pattern electroretinogram (PERG), mean retinal nerve fiber layer thickness (RNFLT), and standard automated perimetry...

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Bibliographic Details
Published in:Documenta ophthalmologica 2020-10, Vol.141 (2), p.149-156
Main Authors: Gordon, Phillip S., Kostic, Maja, Monsalve, Pedro F., Triolo, Giacinto, Golubev, Luri, Luna, Gabriel, Ventura, Lori M., Feuer, William J., Porciatti, Vittorio
Format: Article
Language:English
Subjects:
Adult
Antihypertensive Agents - therapeutic use
Disease Progression
Electroretinography - methods
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Nerve Fibers - physiology
Ocular Hypertension - diagnosis
Ocular Hypertension - drug therapy
Ocular Hypertension - physiopathology
Ophthalmology
Original Research Article
Pattern Recognition, Visual - physiology
Retinal Ganglion Cells - physiology
Retrospective Studies
Visual Field Tests - methods
Visual Fields - physiology
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Summary:Purpose To investigate long-term structural and functional progression of untreated and treated glaucoma suspects (UGS and TGS). Methods Retrospective analysis of serial steady-state pattern electroretinogram (PERG), mean retinal nerve fiber layer thickness (RNFLT), and standard automated perimetry mean deviation (SAP-MD) in UGS ( N  = 20) and TGS ( N  = 18). Outcome measures were the rates of change (linear regression slopes) of PERG amplitude, PERG phase, mean RNFLT, and SAP-MD over 9.8 ± 1.3 years (15.6 ± 4.2 visits). Results The number of patients with significant ( P  
ISSN:0012-4486
1573-2622
DOI:10.1007/s10633-020-09760-5