Neuroprotective effects of vomifoliol, isolated from Tarenna obtusifolia Merr. (Rubiaceae), against amyloid-beta1-42-treated neuroblastoma SH-SY5Y cells

Phytochemical investigation on the leaves of Tarenna obtusifolia Merr. (Rubiaceae) led to the isolation and identification of vomifoliol ( 1 ), p -coumaric acid ( 2 ), and stigmasterol ( 3 ) based on spectroscopic analyses and comparison with the literature data. Compound 1 moderately inhibited the...

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Bibliographic Details
Published in:3 Biotech 2020-09, Vol.10 (10), Article 424
Main Authors: Tan, Mario A., Gonzalez, Sebastian Jesus B., Alejandro, Grecebio Jonathan D., An, Seong Soo A.
Format: Article
Language:English
Subjects:
Agglomeration
Agriculture
Bioinformatics
Biomaterials
Biotechnology
Cancer Research
Chemistry
Chemistry and Materials Science
Coumaric acid
Cytotoxicity
Neuroblastoma
Neuroprotection
p-Coumaric acid
Phytochemicals
Rubiaceae
Short Reports
Stem Cells
Toxicity
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Summary:Phytochemical investigation on the leaves of Tarenna obtusifolia Merr. (Rubiaceae) led to the isolation and identification of vomifoliol ( 1 ), p -coumaric acid ( 2 ), and stigmasterol ( 3 ) based on spectroscopic analyses and comparison with the literature data. Compound 1 moderately inhibited the aggregation of amyloid- beta (Aβ 1–42 ) using the ThT assay (55.71% at 50 μM) and exhibited neuroprotective effects against amyloid- beta (Aβ 1–42 )-induced cytotoxicity in neuroblastoma SH-SY5Y cells at 20 μM concentration. This is the first phytochemical study on T. obtusifolia and the first report on the Aβ aggregation activity and neuroprotective potential of vomifoliol ( 1 ).
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-020-02421-z