APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis

The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light on our understanding of the...

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Bibliographic Details
Published in:Seminars in cancer biology 2020-12, Vol.67 (Pt 2), p.80-91
Main Authors: Schrock, Morgan S., Stromberg, Benjamin R., Scarberry, Luke, Summers, Matthew K.
Format: Article
Language:English
Subjects:
Anaphase promoting complex/ cyclosome
Cancer
Cdc20
Cdh1
Genome instability
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Summary:The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light on our understanding of the role of APC/C coactivators, Cdh1 and Cdc20, in cancer initiation and development. We summarize the current state of knowledge regarding APC/C structure and function, as well as the distinct ways Cdh1 and Cdc20 are dysregulated in human cancer. We also discuss APC/C inhibitors, novel approaches for targeting the APC/C as a cancer therapy, and areas for future work.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2020.03.001