Age, Sex, and Depot‐Specific Differences in Adipose‐Tissue Estrogen Receptors in Individuals with Obesity

Objective The aim of this study was to examine the effects of sex and menopausal status on depot‐specific estrogen signaling in white adipose tissue (AT) in age‐matched men and women with morbid obesity. Methods A total of 28 premenopausal women, 16 postmenopausal women, and 27 age‐matched men under...

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Published in:Obesity (Silver Spring, Md.) Md.), 2020-09, Vol.28 (9), p.1698-1707
Main Authors: Porter, Jay W., Barnas, Jillian L., Welly, Rebecca, Spencer, Nicole, Pitt, James, Vieira‐Potter, Victoria J., Kanaley, Jill A.
Format: Article
Language:English
Subjects:
Adipocytes
Adipose Tissue - metabolism
Adult
Age
Age Factors
Aged
Body fat
Cardiovascular disease
Cholesterol
Estrogens
Fatty acids
Female
Gastrointestinal surgery
Gene expression
Glucose
Humans
Insulin resistance
Kinases
Lipids
Male
Menopause
Metabolism
Middle Aged
Obesity
Obesity - epidemiology
Obesity - metabolism
Polymerase chain reaction
Proteins
Questionnaires
Receptors, Estrogen - metabolism
Sex Characteristics
Sexes
Software
Triglycerides
Womens health
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Summary:Objective The aim of this study was to examine the effects of sex and menopausal status on depot‐specific estrogen signaling in white adipose tissue (AT) in age‐matched men and women with morbid obesity. Methods A total of 28 premenopausal women, 16 postmenopausal women, and 27 age‐matched men undergoing bariatric surgery were compared for omental (OM) AT (OMAT) and abdominal subcutaneous (SQ) AT (SQAT) genes and proteins. Results With the exception of fasting nonesterified fatty acids being higher in women (P 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.22888