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Increasing Fatty Acid Oxidation Prevents High-Fat Diet–Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy
Increased fatty acid oxidation (FAO) has long been considered a culprit in the development of obesity/diabetes mellitus-induced cardiomyopathy. However, enhancing cardiac FAO by removing the inhibitory mechanism of long-chain fatty acid transport into mitochondria via deletion of acetyl coenzyme A c...
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Published in: | Circulation (New York, N.Y.) N.Y.), 2020-09, Vol.142 (10), p.983-997 |
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creator | Shao, Dan Kolwicz, Stephen C. Wang, Pei Roe, Nathan D. Villet, Outi Nishi, Kiyoto Hsu, Yun-Wei A. Flint, Galina V. Caudal, Arianne Wang, Wang Regnier, Michael Tian, Rong |
description | Increased fatty acid oxidation (FAO) has long been considered a culprit in the development of obesity/diabetes mellitus-induced cardiomyopathy. However, enhancing cardiac FAO by removing the inhibitory mechanism of long-chain fatty acid transport into mitochondria via deletion of acetyl coenzyme A carboxylase 2 (ACC2) does not cause cardiomyopathy in nonobese mice, suggesting that high FAO is distinct from cardiac lipotoxicity. We hypothesize that cardiac pathology-associated obesity is attributable to the imbalance of fatty acid supply and oxidation. Thus, we here seek to determine whether further increasing FAO by inducing ACC2 deletion prevents obesity-induced cardiomyopathy, and if so, to elucidate the underlying mechanisms.
We induced high FAO in adult mouse hearts by cardiac-specific deletion of ACC2 using a tamoxifen-inducible model (ACC2 iKO). Control and ACC2 iKO mice were subjected to high-fat diet (HFD) feeding for 24 weeks to induce obesity. Cardiac function, mitochondria function, and mitophagy activity were examined.
Despite both control and ACC2 iKO mice exhibiting a similar obese phenotype, increasing FAO oxidation by deletion of ACC2 prevented HFD-induced cardiac dysfunction, pathological remodeling, and mitochondria dysfunction, as well. Similarly, increasing FAO by knockdown of ACC2 prevented palmitate-induced mitochondria dysfunction and cardiomyocyte death in vitro. Furthermore, HFD suppressed mitophagy activity and caused damaged mitochondria to accumulate in the heart, which was attenuated, in part, in the ACC2 iKO heart. Mechanistically, ACC2 iKO prevented HFD-induced downregulation of parkin. During stimulation for mitophagy, mitochondria-localized parkin was severely reduced in control HFD-fed mouse heart, which was restored, in part, in ACC2 iKO HFD-fed mice.
These data show that increasing cardiac FAO alone does not cause cardiac dysfunction, but protects against cardiomyopathy in chronically obese mice. The beneficial effect of enhancing cardiac FAO in HFD-induced obesity is mediated, in part, by the maintenance of mitochondria function through regulating parkin-mediated mitophagy. Our findings also suggest that targeting the parkin-dependent mitophagy pathway could be an effective strategy against the development of obesity-induced cardiomyopathy. |
doi_str_mv | 10.1161/CIRCULATIONAHA.119.043319 |
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We induced high FAO in adult mouse hearts by cardiac-specific deletion of ACC2 using a tamoxifen-inducible model (ACC2 iKO). Control and ACC2 iKO mice were subjected to high-fat diet (HFD) feeding for 24 weeks to induce obesity. Cardiac function, mitochondria function, and mitophagy activity were examined.
Despite both control and ACC2 iKO mice exhibiting a similar obese phenotype, increasing FAO oxidation by deletion of ACC2 prevented HFD-induced cardiac dysfunction, pathological remodeling, and mitochondria dysfunction, as well. Similarly, increasing FAO by knockdown of ACC2 prevented palmitate-induced mitochondria dysfunction and cardiomyocyte death in vitro. Furthermore, HFD suppressed mitophagy activity and caused damaged mitochondria to accumulate in the heart, which was attenuated, in part, in the ACC2 iKO heart. Mechanistically, ACC2 iKO prevented HFD-induced downregulation of parkin. During stimulation for mitophagy, mitochondria-localized parkin was severely reduced in control HFD-fed mouse heart, which was restored, in part, in ACC2 iKO HFD-fed mice.
These data show that increasing cardiac FAO alone does not cause cardiac dysfunction, but protects against cardiomyopathy in chronically obese mice. The beneficial effect of enhancing cardiac FAO in HFD-induced obesity is mediated, in part, by the maintenance of mitochondria function through regulating parkin-mediated mitophagy. Our findings also suggest that targeting the parkin-dependent mitophagy pathway could be an effective strategy against the development of obesity-induced cardiomyopathy.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.119.043319</identifier><identifier>PMID: 32597196</identifier><language>eng</language><publisher>United States: by the American College of Cardiology Foundation and the American Heart Association, Inc</publisher><subject>Acetyl-CoA Carboxylase - genetics ; Acetyl-CoA Carboxylase - metabolism ; Animals ; Cardiomyopathies - chemically induced ; Cardiomyopathies - genetics ; Cardiomyopathies - metabolism ; Cardiomyopathies - prevention & control ; Diet, High-Fat - adverse effects ; Fatty Acids - metabolism ; Mice ; Mice, Knockout ; Mitochondria, Heart - genetics ; Mitochondria, Heart - metabolism ; Mitophagy - drug effects ; Mitophagy - genetics ; Oxidation-Reduction - drug effects ; Ubiquitin-Protein Ligases - genetics ; Ubiquitin-Protein Ligases - metabolism</subject><ispartof>Circulation (New York, N.Y.), 2020-09, Vol.142 (10), p.983-997</ispartof><rights>by the American College of Cardiology Foundation and the American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5908-cca51177184d1b33e1e3d91b181c5e86fe8dda30fbf16952daa9d01f9f0a33b33</citedby><cites>FETCH-LOGICAL-c5908-cca51177184d1b33e1e3d91b181c5e86fe8dda30fbf16952daa9d01f9f0a33b33</cites><orcidid>0000-0001-9093-412X ; 0000-0002-3676-3830</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32597196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shao, Dan</creatorcontrib><creatorcontrib>Kolwicz, Stephen C.</creatorcontrib><creatorcontrib>Wang, Pei</creatorcontrib><creatorcontrib>Roe, Nathan D.</creatorcontrib><creatorcontrib>Villet, Outi</creatorcontrib><creatorcontrib>Nishi, Kiyoto</creatorcontrib><creatorcontrib>Hsu, Yun-Wei A.</creatorcontrib><creatorcontrib>Flint, Galina V.</creatorcontrib><creatorcontrib>Caudal, Arianne</creatorcontrib><creatorcontrib>Wang, Wang</creatorcontrib><creatorcontrib>Regnier, Michael</creatorcontrib><creatorcontrib>Tian, Rong</creatorcontrib><title>Increasing Fatty Acid Oxidation Prevents High-Fat Diet–Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Increased fatty acid oxidation (FAO) has long been considered a culprit in the development of obesity/diabetes mellitus-induced cardiomyopathy. However, enhancing cardiac FAO by removing the inhibitory mechanism of long-chain fatty acid transport into mitochondria via deletion of acetyl coenzyme A carboxylase 2 (ACC2) does not cause cardiomyopathy in nonobese mice, suggesting that high FAO is distinct from cardiac lipotoxicity. We hypothesize that cardiac pathology-associated obesity is attributable to the imbalance of fatty acid supply and oxidation. Thus, we here seek to determine whether further increasing FAO by inducing ACC2 deletion prevents obesity-induced cardiomyopathy, and if so, to elucidate the underlying mechanisms.
We induced high FAO in adult mouse hearts by cardiac-specific deletion of ACC2 using a tamoxifen-inducible model (ACC2 iKO). Control and ACC2 iKO mice were subjected to high-fat diet (HFD) feeding for 24 weeks to induce obesity. Cardiac function, mitochondria function, and mitophagy activity were examined.
Despite both control and ACC2 iKO mice exhibiting a similar obese phenotype, increasing FAO oxidation by deletion of ACC2 prevented HFD-induced cardiac dysfunction, pathological remodeling, and mitochondria dysfunction, as well. Similarly, increasing FAO by knockdown of ACC2 prevented palmitate-induced mitochondria dysfunction and cardiomyocyte death in vitro. Furthermore, HFD suppressed mitophagy activity and caused damaged mitochondria to accumulate in the heart, which was attenuated, in part, in the ACC2 iKO heart. Mechanistically, ACC2 iKO prevented HFD-induced downregulation of parkin. During stimulation for mitophagy, mitochondria-localized parkin was severely reduced in control HFD-fed mouse heart, which was restored, in part, in ACC2 iKO HFD-fed mice.
These data show that increasing cardiac FAO alone does not cause cardiac dysfunction, but protects against cardiomyopathy in chronically obese mice. The beneficial effect of enhancing cardiac FAO in HFD-induced obesity is mediated, in part, by the maintenance of mitochondria function through regulating parkin-mediated mitophagy. Our findings also suggest that targeting the parkin-dependent mitophagy pathway could be an effective strategy against the development of obesity-induced cardiomyopathy.</description><subject>Acetyl-CoA Carboxylase - genetics</subject><subject>Acetyl-CoA Carboxylase - metabolism</subject><subject>Animals</subject><subject>Cardiomyopathies - chemically induced</subject><subject>Cardiomyopathies - genetics</subject><subject>Cardiomyopathies - metabolism</subject><subject>Cardiomyopathies - prevention & control</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Fatty Acids - metabolism</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mitochondria, Heart - genetics</subject><subject>Mitochondria, Heart - metabolism</subject><subject>Mitophagy - drug effects</subject><subject>Mitophagy - genetics</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Ubiquitin-Protein Ligases - genetics</subject><subject>Ubiquitin-Protein Ligases - metabolism</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkc1u1DAUhS0EokPhFVDYsUnxjZ0fb5CigTKRpkxVTdeWx3YS00w82E5LJBa8A2_Ik-BqSkVXls8959hXH0LvAJ8BFPBh2Vwtr9f1ttl8rVd11NgZpoQAe4YWkGc0pTlhz9ECY8zSkmTZCXrl_bd4LUiZv0QnJMtZCaxYoJ_NKJ0W3oxdci5CmJNaGpVsfhglgrFjcun0rR6DT1am69NoST4ZHf78-t2MapJaJUvhlLH72R5E6Odk2zs7dX1ypbtpiBWx91K4GzOmF1oZEWLiwgR76EU3v0YvWjF4_ebhPEXX55-3y1W63nxplvU6lTnDVSqlyAHKEiqqYEeIBk0Ugx1UIHNdFa2ulBIEt7sWCpZnSgimMLSsxYKQGDhFH4-9h2m310rGfZwY-MGZvXAzt8Lwp5PR9Lyzt7ykFaUUx4L3DwXOfp-0D3xvvNTDIEZtJ88zClWZlTSn0cqOVums9063j88A5vf0-FN6UWP8SC9m3_7_z8fkP1zRQI-GOzsE7fzNMN1px3sthtDzyBcTDGWa4SySxxVO76WK_AWqhaul</recordid><startdate>20200908</startdate><enddate>20200908</enddate><creator>Shao, Dan</creator><creator>Kolwicz, Stephen C.</creator><creator>Wang, Pei</creator><creator>Roe, Nathan D.</creator><creator>Villet, Outi</creator><creator>Nishi, Kiyoto</creator><creator>Hsu, Yun-Wei A.</creator><creator>Flint, Galina V.</creator><creator>Caudal, Arianne</creator><creator>Wang, Wang</creator><creator>Regnier, Michael</creator><creator>Tian, Rong</creator><general>by the American College of Cardiology Foundation and the American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9093-412X</orcidid><orcidid>https://orcid.org/0000-0002-3676-3830</orcidid></search><sort><creationdate>20200908</creationdate><title>Increasing Fatty Acid Oxidation Prevents High-Fat Diet–Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy</title><author>Shao, Dan ; 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However, enhancing cardiac FAO by removing the inhibitory mechanism of long-chain fatty acid transport into mitochondria via deletion of acetyl coenzyme A carboxylase 2 (ACC2) does not cause cardiomyopathy in nonobese mice, suggesting that high FAO is distinct from cardiac lipotoxicity. We hypothesize that cardiac pathology-associated obesity is attributable to the imbalance of fatty acid supply and oxidation. Thus, we here seek to determine whether further increasing FAO by inducing ACC2 deletion prevents obesity-induced cardiomyopathy, and if so, to elucidate the underlying mechanisms.
We induced high FAO in adult mouse hearts by cardiac-specific deletion of ACC2 using a tamoxifen-inducible model (ACC2 iKO). Control and ACC2 iKO mice were subjected to high-fat diet (HFD) feeding for 24 weeks to induce obesity. Cardiac function, mitochondria function, and mitophagy activity were examined.
Despite both control and ACC2 iKO mice exhibiting a similar obese phenotype, increasing FAO oxidation by deletion of ACC2 prevented HFD-induced cardiac dysfunction, pathological remodeling, and mitochondria dysfunction, as well. Similarly, increasing FAO by knockdown of ACC2 prevented palmitate-induced mitochondria dysfunction and cardiomyocyte death in vitro. Furthermore, HFD suppressed mitophagy activity and caused damaged mitochondria to accumulate in the heart, which was attenuated, in part, in the ACC2 iKO heart. Mechanistically, ACC2 iKO prevented HFD-induced downregulation of parkin. During stimulation for mitophagy, mitochondria-localized parkin was severely reduced in control HFD-fed mouse heart, which was restored, in part, in ACC2 iKO HFD-fed mice.
These data show that increasing cardiac FAO alone does not cause cardiac dysfunction, but protects against cardiomyopathy in chronically obese mice. The beneficial effect of enhancing cardiac FAO in HFD-induced obesity is mediated, in part, by the maintenance of mitochondria function through regulating parkin-mediated mitophagy. Our findings also suggest that targeting the parkin-dependent mitophagy pathway could be an effective strategy against the development of obesity-induced cardiomyopathy.</abstract><cop>United States</cop><pub>by the American College of Cardiology Foundation and the American Heart Association, Inc</pub><pmid>32597196</pmid><doi>10.1161/CIRCULATIONAHA.119.043319</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-9093-412X</orcidid><orcidid>https://orcid.org/0000-0002-3676-3830</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Acetyl-CoA Carboxylase - genetics Acetyl-CoA Carboxylase - metabolism Animals Cardiomyopathies - chemically induced Cardiomyopathies - genetics Cardiomyopathies - metabolism Cardiomyopathies - prevention & control Diet, High-Fat - adverse effects Fatty Acids - metabolism Mice Mice, Knockout Mitochondria, Heart - genetics Mitochondria, Heart - metabolism Mitophagy - drug effects Mitophagy - genetics Oxidation-Reduction - drug effects Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism |
title | Increasing Fatty Acid Oxidation Prevents High-Fat Diet–Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy |
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