Association between serum soluble receptor for advanced glycation end-products (RAGE) deficiency and severity of clinicopathologic evidence of canine chronic inflammatory enteropathy

• Published in: Journal of veterinary diagnostic investigation 2020-09, Vol.32 (5), p.664-674
• Main Authors: Cabrera-García, Angela Isabel, Suchodolski, Jan S., Steiner, Jörg M., Heilmann, Romy M.
• Format: Article
• Language: English
• Subjects: Animals; Biomarkers - blood; Blood - metabolism; Blood Chemical Analysis - veterinary; Chronic Disease - veterinary; Dog Diseases - diagnosis; Dogs; Female; Full Scientific Report; Inflammation - diagnosis; Inflammation - veterinary; Male; Receptor for Advanced Glycation End Products - blood; Receptor for Advanced Glycation End Products - deficiency; Severity of Illness Index
• ISSN: 1040-6387; 1943-4936
• DOI: 10.1177/1040638720943584

Innate immunity plays a central role in the pathogenesis of chronic inflammatory enteropathies (CIE) in dogs, and further evaluation of the innate immune receptor for advanced glycation end-products (RAGE) is warranted. We measured serum concentrations of decoy receptor soluble RAGE (sRAGE) in 102 dogs diagnosed with CIE, and evaluated relationships with clinical disease severity, histologic lesion severity, concentrations of serum C-reactive protein (CRP), and serum and fecal calprotectin, S100A12, and alpha1-proteinase inhibitor (α1PI). Serum sRAGE levels were not associated with clinical disease activity, serum CRP, serum and fecal α1PI, calprotectin, or S100A12 concentrations. Microscopic lesions in the duodenum were more severe in dogs with serum sRAGE concentration ≤ 340 ng/L (p = 0.013). Serum sRAGE levels were weakly and inversely correlated with the severity of lymphoplasmacytic infiltration in the gastric antrum and duodenum, and with crypt dilation and the neutrophilic infiltrate in the duodenum, in univariate analysis (all p