Differential expression of peptides serves as an indicator of IgA nephropathy in pediatric patients

Peptide profiles change significantly with aging and peptide biomarkers discovered in adult patients may not be suitable for the evaluation of pediatric patients. The present study was designed to explore alterations in the serum peptidome profile of pediatric patients with IgA nephropathy (IgAN). A...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2020-11, Vol.20 (5), p.1-1
Main Authors: Rao, Chunbao, Yang, Fan, Lai, Zhijun, Chen, Sujun, Lu, Xiaomei, Jiang, Xiaoyun
Format: Article
Language:English
Subjects:
Age
Biomarkers
Biopsy
Child health
Chromatography
Disease
EDTA
Genomics
Health aspects
Immunoglobulin A
Kidney diseases
Liquid chromatography
Mass spectrometry
Medical research
Pediatrics
Peptides
Proteins
Scientific imaging
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Summary:Peptide profiles change significantly with aging and peptide biomarkers discovered in adult patients may not be suitable for the evaluation of pediatric patients. The present study was designed to explore alterations in the serum peptidome profile of pediatric patients with IgA nephropathy (IgAN). A total of 17 children diagnosed with IgAN were recruited as the experimental group, 11 sex-matched healthy children were recruited as a healthy control group and 18 sex-matched children with other glomerular diseases were recruited as a disease control group. Serum peptides of each subject were enriched and analyzed by liquid chromatography with tandem mass spectrometry and the subsequently identified IgAN-specific peptides were evaluated using Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis. Subsequently, the function of the IgAN-specific peptides was predicted via sequence comparison with other known functional bioactive peptides. A total of 123 peptides with a fold change >2 (P5 (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2020.9195