Evaluation of the Risk of Getting Peripheral Artery Disease in Rheumatoid Arthritis and the Selection of Appropriate Diagnostic Methods

This study aims to review the evidence regarding the association between peripheral artery disease (PAD) and rheumatoid arthritis (RA), as well as influential underlying factors and diagnostic options. Eligible literature was searched in PubMed published up to June 1, 2020, in English. Case studies,...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-08, Vol.12 (8), p.e9782-e9782
Main Authors: Sedrakyan, Surik, Fatima, Tehreem, Khatun, Mst. Khaleda, Awan, Muhammad R, Okam, Nkechi A, Jahan, Nusrat
Format: Article
Language:English
Subjects:
Cardiology
Internal Medicine
Rheumatology
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Summary:This study aims to review the evidence regarding the association between peripheral artery disease (PAD) and rheumatoid arthritis (RA), as well as influential underlying factors and diagnostic options. Eligible literature was searched in PubMed published up to June 1, 2020, in English. Case studies, case series, reviews, and meta-analyses were excluded. We also excluded non-human studies and those 20 years and older. A total of 44 studies were finally incorporated in the narrative review. The results indicated that compared to controls, RA patients are more prone to PAD. Traditional risk factors, disease-characteristics, vitamin D deficiency, therapy used, and other relevant conditions have a variable effect on overall PAD progression. Studies comparing diagnostic options revealed that vascular function and morphology are connected but are still distinctive processes. In early-stage disease, there are functional alterations in the endothelium that can be controlled by anti-inflammatory medications. Ankle-Brachial Index (ABI)
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.9782