The associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes

• Published in: Diabetes research and clinical practice 2020-11, Vol.169, p.108448-108448, Article 108448
• Main Authors: Huang, Yun, Guo, Heming, Zhou, Yan, Guo, Jingjing, Wang, Tiantian, Zhao, Xuming, Li, Hui, Sun, Yihui, Bian, Xuna, Fang, Chen
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Blood Glucose - analysis; China - epidemiology; COVID-19; COVID-19 - blood; COVID-19 - epidemiology; COVID-19 - mortality; COVID-19 - virology; Diabetes Mellitus; Fasting; Female; Humans; Male; Middle Aged; Mortality; Plasma glucose; Prognosis; Retrospective Studies; Risk Factors; SARS-CoV-2 - isolation & purification; Survival Rate
• ISSN: 0168-8227; 1872-8227; 1872-8227
• DOI: 10.1016/j.diabres.2020.108448

Coronavirus disease 2019 (COVID-19) which is a novel pneumonia can rapidly progress to acute respiratory distress syndrome, septic shock, and multiple organ dysfunction syndrome. It has appeared in 196 countries around the world. We aimed to clarify the associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes. We performed a retrospective, single-center study of 151 patients without diabetes in Tongji Hospital from January 1, 2020 to February 28, 2020. Past medical histories, clinical features and laboratory parameters were collected in these patients. Compared with survivors, non-survivors were more likely to have underlying medical conditions including hypertension and chronic pulmonary diseases. Non-survivors had higher C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-2R, IL-6, IL-8 and, tumor necrosis factor-α (TNF-α) levels, while lower lymphocyte counts as compared with those of survivors (all P