Profiles of overall survival-related gene expression-based risk signature and their prognostic implications in clear cell renal cell carcinoma

The present work aimed to evaluate the prognostic value of overall survival (OS)-related genes in clear cell renal cell carcinoma (ccRCC) and to develop a nomogram for clinical use. Transcriptome data from The Cancer Genome Atlas (TCGA) were collected to screen differentially expressed genes (DEGs)...

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Bibliographic Details
Published in:Bioscience reports 2020-09, Vol.40 (9)
Main Authors: He, Zihao, Deng, Tuo, Duan, Xiaolu, Zeng, Guohua
Format: Article
Language:English
Subjects:
Aged
Bioinformatics
Cancer
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - mortality
Data Mining
Diagnostics & Biomarkers
Female
Gastrointestinal, Renal & Hepatic Systems
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms - genetics
Kidney Neoplasms - mortality
Male
Middle Aged
Nomograms
Prognosis
Reproducibility of Results
Transcriptome
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Summary:The present work aimed to evaluate the prognostic value of overall survival (OS)-related genes in clear cell renal cell carcinoma (ccRCC) and to develop a nomogram for clinical use. Transcriptome data from The Cancer Genome Atlas (TCGA) were collected to screen differentially expressed genes (DEGs) between ccRCC patients with OS > 5 years (149 patients) and those with
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20200492