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Glucocorticoid Resistance is Associated with Poor Functional Outcome After Stroke
Systemic inflammation is associated with poor outcome after stroke. Glucocorticoids (GCs) play a fundamental role in limiting inflammation. The aim of this study was to explore the associations between GC sensitivity, systemic inflammation, and outcome after ischemic stroke. The study population com...
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| Published in: | Cellular and molecular neurobiology 2020-11, Vol.40 (8), p.1321-1326 |
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| Main Authors: | , , , , , |
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| container_end_page | 1326 |
| container_issue | 8 |
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| container_title | Cellular and molecular neurobiology |
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| creator | Lopatkiewicz, Anna Maria Gradek-Kwinta, Elzbieta Czyzycki, Mateusz Pera, Joanna Slowik, Agnieszka Dziedzic, Tomasz |
| description | Systemic inflammation is associated with poor outcome after stroke. Glucocorticoids (GCs) play a fundamental role in limiting inflammation. The aim of this study was to explore the associations between GC sensitivity, systemic inflammation, and outcome after ischemic stroke. The study population compised 246 ischemic stroke patients (median age: 69.0 years; 41.1% female). To assess GC sensitivity, we incubated venous blood samples that were obtained at day 3 after stroke with lipopolysaccharide (10 ng/mL) and dexamethasone (10
–6
mol/L). We defined the GC sensitivity index as the ratio of tumor necrosis factor α (TNFα) released after blood stimulation with lipopolysaccharide and dexamethasone to the amount of TNFα released after blood stimulation with lipopolysaccharide alone. A higher index indicates higher GC resistance. The patients with poor functional outcome had a higher GC sensitivity index than those with good outcome (median: 16.1% vs. 13.5%,
P
|
| doi_str_mv | 10.1007/s10571-020-00818-1 |
| format | article |
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–6
mol/L). We defined the GC sensitivity index as the ratio of tumor necrosis factor α (TNFα) released after blood stimulation with lipopolysaccharide and dexamethasone to the amount of TNFα released after blood stimulation with lipopolysaccharide alone. A higher index indicates higher GC resistance. The patients with poor functional outcome had a higher GC sensitivity index than those with good outcome (median: 16.1% vs. 13.5%,
P
< 0.01). In a logistic regression analysis adjusted for age, stroke severity, pneumonia, leukocyte count, plasma interleukin-6, and TNFα release ex vivo, a higher GC sensitivity index was associated with a higher risk of poor outcome after stroke (OR 2.32, 95% CI 1.21–4.45,
P
= 0.01). In conclusion, GC resistance is associated with poor functional outcome after stroke.</description><identifier>ISSN: 0272-4340</identifier><identifier>EISSN: 1573-6830</identifier><identifier>DOI: 10.1007/s10571-020-00818-1</identifier><identifier>PMID: 32107751</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Dexamethasone ; Glucocorticoids ; Inflammation ; Interleukin 6 ; Ischemia ; Lipopolysaccharides ; Neurobiology ; Neurosciences ; Original Research ; Population studies ; Stroke ; Tumor necrosis factor-α</subject><ispartof>Cellular and molecular neurobiology, 2020-11, Vol.40 (8), p.1321-1326</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-e8a180b112142c5873b925c29d7371600f64132f634b99a5692419d74a4ca8bf3</citedby><cites>FETCH-LOGICAL-c474t-e8a180b112142c5873b925c29d7371600f64132f634b99a5692419d74a4ca8bf3</cites><orcidid>0000-0003-4086-0729</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32107751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopatkiewicz, Anna Maria</creatorcontrib><creatorcontrib>Gradek-Kwinta, Elzbieta</creatorcontrib><creatorcontrib>Czyzycki, Mateusz</creatorcontrib><creatorcontrib>Pera, Joanna</creatorcontrib><creatorcontrib>Slowik, Agnieszka</creatorcontrib><creatorcontrib>Dziedzic, Tomasz</creatorcontrib><title>Glucocorticoid Resistance is Associated with Poor Functional Outcome After Stroke</title><title>Cellular and molecular neurobiology</title><addtitle>Cell Mol Neurobiol</addtitle><addtitle>Cell Mol Neurobiol</addtitle><description>Systemic inflammation is associated with poor outcome after stroke. Glucocorticoids (GCs) play a fundamental role in limiting inflammation. The aim of this study was to explore the associations between GC sensitivity, systemic inflammation, and outcome after ischemic stroke. The study population compised 246 ischemic stroke patients (median age: 69.0 years; 41.1% female). To assess GC sensitivity, we incubated venous blood samples that were obtained at day 3 after stroke with lipopolysaccharide (10 ng/mL) and dexamethasone (10
–6
mol/L). We defined the GC sensitivity index as the ratio of tumor necrosis factor α (TNFα) released after blood stimulation with lipopolysaccharide and dexamethasone to the amount of TNFα released after blood stimulation with lipopolysaccharide alone. A higher index indicates higher GC resistance. The patients with poor functional outcome had a higher GC sensitivity index than those with good outcome (median: 16.1% vs. 13.5%,
P
< 0.01). In a logistic regression analysis adjusted for age, stroke severity, pneumonia, leukocyte count, plasma interleukin-6, and TNFα release ex vivo, a higher GC sensitivity index was associated with a higher risk of poor outcome after stroke (OR 2.32, 95% CI 1.21–4.45,
P
= 0.01). In conclusion, GC resistance is associated with poor functional outcome after stroke.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Dexamethasone</subject><subject>Glucocorticoids</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Ischemia</subject><subject>Lipopolysaccharides</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Original Research</subject><subject>Population studies</subject><subject>Stroke</subject><subject>Tumor necrosis factor-α</subject><issn>0272-4340</issn><issn>1573-6830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kctOHDEQRS0UBBOSH8gispRNNg1VfrTbm0gjBCQSEpDH2nJ73GDS0ya2O4i_j8PwSLKIVJIX99Stcl1C3iDsI4A6yAhSYQMMGoAOuwa3yAKl4k3bcXhBFsAUawQXsEte5nwNABpA7pBdzhCUkrggFyfj7KKLqQQXw4p-9jnkYifnach0mXN0wRa_orehXNHzGBM9nidXQpzsSM_m4uLa0-VQfKJfSorf_SuyPdgx-9cP7x75dnz09fBjc3p28ulwedo4oURpfGexgx6RoWBOdor3mknH9EpxhS3A0ArkbGi56LW2stVMYBWFFc52_cD3yIeN783cr_3K-akkO5qbFNY23Zlog_lbmcKVuYw_jRK6lqwG7x8MUvwx-1zMOmTnx9FOPs7ZMN5qXvfSXUXf_YNexznVC1RKSGBtPaiqFNtQLsWckx-elkEwvxMzm8RMTczcJ2awNr398xtPLY8RVYBvgFyl6dKn59n_sf0FcImghA</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Lopatkiewicz, Anna Maria</creator><creator>Gradek-Kwinta, Elzbieta</creator><creator>Czyzycki, Mateusz</creator><creator>Pera, Joanna</creator><creator>Slowik, Agnieszka</creator><creator>Dziedzic, Tomasz</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4086-0729</orcidid></search><sort><creationdate>20201101</creationdate><title>Glucocorticoid Resistance is Associated with Poor Functional Outcome After Stroke</title><author>Lopatkiewicz, Anna Maria ; Gradek-Kwinta, Elzbieta ; Czyzycki, Mateusz ; Pera, Joanna ; Slowik, Agnieszka ; Dziedzic, Tomasz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-e8a180b112142c5873b925c29d7371600f64132f634b99a5692419d74a4ca8bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Dexamethasone</topic><topic>Glucocorticoids</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Ischemia</topic><topic>Lipopolysaccharides</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Original Research</topic><topic>Population studies</topic><topic>Stroke</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopatkiewicz, Anna Maria</creatorcontrib><creatorcontrib>Gradek-Kwinta, Elzbieta</creatorcontrib><creatorcontrib>Czyzycki, Mateusz</creatorcontrib><creatorcontrib>Pera, Joanna</creatorcontrib><creatorcontrib>Slowik, Agnieszka</creatorcontrib><creatorcontrib>Dziedzic, Tomasz</creatorcontrib><collection>Springer_OA刊</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopatkiewicz, Anna Maria</au><au>Gradek-Kwinta, Elzbieta</au><au>Czyzycki, Mateusz</au><au>Pera, Joanna</au><au>Slowik, Agnieszka</au><au>Dziedzic, Tomasz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucocorticoid Resistance is Associated with Poor Functional Outcome After Stroke</atitle><jtitle>Cellular and molecular neurobiology</jtitle><stitle>Cell Mol Neurobiol</stitle><addtitle>Cell Mol Neurobiol</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>40</volume><issue>8</issue><spage>1321</spage><epage>1326</epage><pages>1321-1326</pages><issn>0272-4340</issn><eissn>1573-6830</eissn><abstract>Systemic inflammation is associated with poor outcome after stroke. Glucocorticoids (GCs) play a fundamental role in limiting inflammation. The aim of this study was to explore the associations between GC sensitivity, systemic inflammation, and outcome after ischemic stroke. The study population compised 246 ischemic stroke patients (median age: 69.0 years; 41.1% female). To assess GC sensitivity, we incubated venous blood samples that were obtained at day 3 after stroke with lipopolysaccharide (10 ng/mL) and dexamethasone (10
–6
mol/L). We defined the GC sensitivity index as the ratio of tumor necrosis factor α (TNFα) released after blood stimulation with lipopolysaccharide and dexamethasone to the amount of TNFα released after blood stimulation with lipopolysaccharide alone. A higher index indicates higher GC resistance. The patients with poor functional outcome had a higher GC sensitivity index than those with good outcome (median: 16.1% vs. 13.5%,
P
< 0.01). In a logistic regression analysis adjusted for age, stroke severity, pneumonia, leukocyte count, plasma interleukin-6, and TNFα release ex vivo, a higher GC sensitivity index was associated with a higher risk of poor outcome after stroke (OR 2.32, 95% CI 1.21–4.45,
P
= 0.01). In conclusion, GC resistance is associated with poor functional outcome after stroke.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32107751</pmid><doi>10.1007/s10571-020-00818-1</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4086-0729</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Cell Biology Dexamethasone Glucocorticoids Inflammation Interleukin 6 Ischemia Lipopolysaccharides Neurobiology Neurosciences Original Research Population studies Stroke Tumor necrosis factor-α |
| title | Glucocorticoid Resistance is Associated with Poor Functional Outcome After Stroke |
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