Commissioning a four‐dimensional Computed Tomography Simulator for minimum target size due to motion in the Anterior–Posterior direction: a procedure and treatment planning recommendations

• Published in: Journal of applied clinical medical physics 2020-09, Vol.21 (9), p.116-123
• Main Authors: Sonier, Marcus, Vangenderen, Brandon, Visagie, Dallas, Appeldoorn, Cameron, Chiang, Te‐Chih (Archie), Mathew, Lindsay, Reinsberg, Stefan, Rose, Jim, Ramaseshan, Ramani
• Format: Article
• Language: English
• Subjects: 4DCT; Algorithms; Aluminum; Carbon fibers; imaging uncertainty; motion management; Radiation Oncology Physics; Radiation therapy; Range of motion; reconstruction artifact; SBRT; Software; Tumors
• ISSN: 1526-9914; 1526-9914
• DOI: 10.1002/acm2.12980

The purpose of this work is to develop a procedure for commissioning four‐dimensional computed tomography (4DCT) algorithms for minimum target reconstruction size, to quantify the effect of anterior–posterior (AP) motion artifacts on known object reconstruction for periodic and irregular breathing patterns, and to provide treatment planning recommendations for target sizes below a minimum threshold. A mechanical platform enabled AP motion of a rod and lung phantom during 4DCT acquisition. Static, artifact‐free scans of the phantoms were first acquired. AP sinusoidal and patient breathing motion was applied to obtain 4DCT images. 4DCT reconstruction artifacts were assessed by measuring the apparent width and angle of the rod. Comparison of known tumor diameters and volumes between the static image parameters with the 4DCT image sets was used to quantify the extent of AP reconstruction artifact and contour deformation. Examination of the rod width, under sinusoidal motion, found it was best represented during the inhale and exhale phases for all periods and ranges of motion. From the gradient phases, the apparent width of the rod decreased with increasing amplitude and decreasing period. The rod angle appeared larger on the reconstructed images due to the presence of motion artifact. The apparent diameters of the spherical tumors on the gradient phases were larger/equivalent than the true values in the AP/LR direction, respectively, while the exhale phase consistently displayed the spheres at the approximately correct diameter. The Eclipse calculated diameter matched closely with the true diameter on the exhale phase and was found to be larger on the inhale, MIP, and Avg scans. The procedure detailed here may be used during the acceptance and commissioning period of a computed tomography simulator or retroactively when implementing a SBRT program to determine the minimum target size that can be reliably reconstructed.