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Green tea consumption increases sperm concentration and viability in male rats and is safe for reproductive, liver and kidney health
Green tea is a popularly consumed beverage worldwide and contains polyphenols, whose antioxidant activities could improve sperm parameters and fertility thereof. We investigated the effect of green tea on the male rat reproductive system as well as its safety. Male Wistar rats were administered 2 an...
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| Published in: | Scientific reports 2020-09, Vol.10 (1), p.15269, Article 15269 |
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| creator | Opuwari, Chinyerum Monsees, Thomas |
| description | Green tea is a popularly consumed beverage worldwide and contains polyphenols, whose antioxidant activities could improve sperm parameters and fertility thereof. We investigated the effect of green tea on the male rat reproductive system as well as its safety. Male Wistar rats were administered 2 and 5% aqueous extract of green tea for 52 days’ ad libitum, while the control group received tap water. Total polyphenol, flavanol, flavonol and soluble solids significantly increased in a concentration-dependent manner in vitro (
P
0.05). Kidney weight, sperm concentration and vitality, spontaneous acrosome reaction increased (
P
0.05). Histological sections of testis, epididymis, kidney and liver showed no conspicuous alteration. Diameter and epithelial height of seminiferous tubule decreased, while caudal epididymis epithelial height increased (
P
|
| doi_str_mv | 10.1038/s41598-020-72319-6 |
| format | article |
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P
< 0.01). Weights of body, testis, epididymis, prostate gland, seminal vesicles, and liver, serum levels of testosterone, ferric reducing antioxidant power, creatinine, and sperm motility, remained unchanged (
P
> 0.05). Kidney weight, sperm concentration and vitality, spontaneous acrosome reaction increased (
P
< 0.05), while alanine transaminase and aspartate transaminase levels decreased (
P
< 0.05). Catalase, superoxide dismutase, glutathione and lipid peroxidation remained unchanged in the testes, liver and kidney (
P
> 0.05). Histological sections of testis, epididymis, kidney and liver showed no conspicuous alteration. Diameter and epithelial height of seminiferous tubule decreased, while caudal epididymis epithelial height increased (
P
< 0.01). Consumption of green tea in the conditions used in the present study seems to be safe and improved sperm parameters. However, subtle structural changes observed in the decreased diameter and epithelial height of the seminiferous tubule and increased acrosome reaction needs further investigation.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-72319-6</identifier><identifier>PMID: 32943691</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443 ; 631/80 ; 692/698 ; Acrosome Reaction - drug effects ; Animals ; Antioxidants - pharmacology ; Catalase - metabolism ; Epididymis - drug effects ; Epididymis - metabolism ; Humanities and Social Sciences ; Kidney - drug effects ; Kidney - metabolism ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Liver - metabolism ; Male ; multidisciplinary ; Oxidative Stress - drug effects ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Reproduction - drug effects ; Science ; Science (multidisciplinary) ; Seminiferous Tubules - drug effects ; Seminiferous Tubules - metabolism ; Sperm Count - methods ; Sperm Motility - drug effects ; Spermatogenesis - drug effects ; Spermatozoa - drug effects ; Spermatozoa - metabolism ; Superoxide Dismutase - metabolism ; Tea - chemistry ; Testis - drug effects ; Testis - metabolism</subject><ispartof>Scientific reports, 2020-09, Vol.10 (1), p.15269, Article 15269</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-b3b498af2793bf299d1f115161de58130f78ce217baf59f3f126746e665d17f13</citedby><cites>FETCH-LOGICAL-c446t-b3b498af2793bf299d1f115161de58130f78ce217baf59f3f126746e665d17f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498455/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498455/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32943691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Opuwari, Chinyerum</creatorcontrib><creatorcontrib>Monsees, Thomas</creatorcontrib><title>Green tea consumption increases sperm concentration and viability in male rats and is safe for reproductive, liver and kidney health</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Green tea is a popularly consumed beverage worldwide and contains polyphenols, whose antioxidant activities could improve sperm parameters and fertility thereof. We investigated the effect of green tea on the male rat reproductive system as well as its safety. Male Wistar rats were administered 2 and 5% aqueous extract of green tea for 52 days’ ad libitum, while the control group received tap water. Total polyphenol, flavanol, flavonol and soluble solids significantly increased in a concentration-dependent manner in vitro (
P
< 0.01). Weights of body, testis, epididymis, prostate gland, seminal vesicles, and liver, serum levels of testosterone, ferric reducing antioxidant power, creatinine, and sperm motility, remained unchanged (
P
> 0.05). Kidney weight, sperm concentration and vitality, spontaneous acrosome reaction increased (
P
< 0.05), while alanine transaminase and aspartate transaminase levels decreased (
P
< 0.05). Catalase, superoxide dismutase, glutathione and lipid peroxidation remained unchanged in the testes, liver and kidney (
P
> 0.05). Histological sections of testis, epididymis, kidney and liver showed no conspicuous alteration. Diameter and epithelial height of seminiferous tubule decreased, while caudal epididymis epithelial height increased (
P
< 0.01). Consumption of green tea in the conditions used in the present study seems to be safe and improved sperm parameters. However, subtle structural changes observed in the decreased diameter and epithelial height of the seminiferous tubule and increased acrosome reaction needs further investigation.</description><subject>631/443</subject><subject>631/80</subject><subject>692/698</subject><subject>Acrosome Reaction - drug effects</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Catalase - metabolism</subject><subject>Epididymis - drug effects</subject><subject>Epididymis - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproduction - drug effects</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Seminiferous Tubules - drug effects</subject><subject>Seminiferous Tubules - metabolism</subject><subject>Sperm Count - methods</subject><subject>Sperm Motility - drug effects</subject><subject>Spermatogenesis - drug effects</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - metabolism</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tea - chemistry</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kc1OxCAUhYnRqFFfwIXhAaz2QqFlY2KMf4mJG10T2l4ctKUNdCaZvQ8uTtXoRhZA8p1zbuAQcgz5GeS8Oo8FCFVlOcuzknFQmdwi-ywvRMY4Y9u_7nvkKMbXPC3BVAFql-zxdOFSwT55vw2Ink5oaDP4uOzHyQ2eOt8ENBEjjSOG_pM16KdgNtT4lq6cqV3npnXS0t50SBOMG-SSy1ikdgg04BiGdtlMboWntEt72GjeXOtxTRdoumlxSHas6SIefZ0H5Pnm-unqLnt4vL2_unzImqKQU1bzulCVsaxUvLZMqRYsgAAJLYoKeG7LqkEGZW2sUJZbYLIsJEopWigt8ANyMeeOy7rHdn5Rp8fgehPWejBO_yXeLfTLsNJlmlsIkQLYHNCEIcaA9scLuf6sRc-16FSL3tSiZTKd_J76Y_kuIQn4LIgJ-RcM-nVYBp9-4r_YD94Pm_Q</recordid><startdate>20200917</startdate><enddate>20200917</enddate><creator>Opuwari, Chinyerum</creator><creator>Monsees, Thomas</creator><general>Nature Publishing Group UK</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200917</creationdate><title>Green tea consumption increases sperm concentration and viability in male rats and is safe for reproductive, liver and kidney health</title><author>Opuwari, Chinyerum ; Monsees, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-b3b498af2793bf299d1f115161de58130f78ce217baf59f3f126746e665d17f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/443</topic><topic>631/80</topic><topic>692/698</topic><topic>Acrosome Reaction - drug effects</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Catalase - metabolism</topic><topic>Epididymis - drug effects</topic><topic>Epididymis - metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproduction - drug effects</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Seminiferous Tubules - drug effects</topic><topic>Seminiferous Tubules - metabolism</topic><topic>Sperm Count - methods</topic><topic>Sperm Motility - drug effects</topic><topic>Spermatogenesis - drug effects</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - metabolism</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Tea - chemistry</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Opuwari, Chinyerum</creatorcontrib><creatorcontrib>Monsees, Thomas</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Opuwari, Chinyerum</au><au>Monsees, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Green tea consumption increases sperm concentration and viability in male rats and is safe for reproductive, liver and kidney health</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-09-17</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>15269</spage><pages>15269-</pages><artnum>15269</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Green tea is a popularly consumed beverage worldwide and contains polyphenols, whose antioxidant activities could improve sperm parameters and fertility thereof. We investigated the effect of green tea on the male rat reproductive system as well as its safety. Male Wistar rats were administered 2 and 5% aqueous extract of green tea for 52 days’ ad libitum, while the control group received tap water. Total polyphenol, flavanol, flavonol and soluble solids significantly increased in a concentration-dependent manner in vitro (
P
< 0.01). Weights of body, testis, epididymis, prostate gland, seminal vesicles, and liver, serum levels of testosterone, ferric reducing antioxidant power, creatinine, and sperm motility, remained unchanged (
P
> 0.05). Kidney weight, sperm concentration and vitality, spontaneous acrosome reaction increased (
P
< 0.05), while alanine transaminase and aspartate transaminase levels decreased (
P
< 0.05). Catalase, superoxide dismutase, glutathione and lipid peroxidation remained unchanged in the testes, liver and kidney (
P
> 0.05). Histological sections of testis, epididymis, kidney and liver showed no conspicuous alteration. Diameter and epithelial height of seminiferous tubule decreased, while caudal epididymis epithelial height increased (
P
< 0.01). Consumption of green tea in the conditions used in the present study seems to be safe and improved sperm parameters. However, subtle structural changes observed in the decreased diameter and epithelial height of the seminiferous tubule and increased acrosome reaction needs further investigation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32943691</pmid><doi>10.1038/s41598-020-72319-6</doi><oa>free_for_read</oa></addata></record> |
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| source | Open Access: PubMed Central; Publicly Available Content Database (Proquest) (PQ_SDU_P3); Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/443 631/80 692/698 Acrosome Reaction - drug effects Animals Antioxidants - pharmacology Catalase - metabolism Epididymis - drug effects Epididymis - metabolism Humanities and Social Sciences Kidney - drug effects Kidney - metabolism Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Male multidisciplinary Oxidative Stress - drug effects Plant Extracts - pharmacology Rats Rats, Wistar Reproduction - drug effects Science Science (multidisciplinary) Seminiferous Tubules - drug effects Seminiferous Tubules - metabolism Sperm Count - methods Sperm Motility - drug effects Spermatogenesis - drug effects Spermatozoa - drug effects Spermatozoa - metabolism Superoxide Dismutase - metabolism Tea - chemistry Testis - drug effects Testis - metabolism |
| title | Green tea consumption increases sperm concentration and viability in male rats and is safe for reproductive, liver and kidney health |
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