Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

• Published in: The pharmacogenomics journal 2020-10, Vol.20 (5), p.621-628
• Main Authors: King, Charlotte, McKenna, Amanda, Farzan, Niloufar, Vijverberg, Susanne J., van der Schee, Marc P., Maitland-van der Zee, Anke H., Arianto, Lambang, Bisgaard, Hans, BØnnelykke, Klaus, Berce, Vojko, PotoČnik, Uros, Repnik, Katja, Carleton, Bruce, Daley, Denise, Chew, Fook Tim, Chiang, Wen Chin, Sio, Yang Yie, Cloutier, Michelle M., Den Dekker, Herman T., Duijts, Liesbeth, de Jongste, Johan C., Dijk, F. Nicole, Flores, Carlos, Hernandez-Pacheco, Natalia, Mukhopadhyay, Somnath, Basu, Kaninika, Tantisira, Kelan G., Verhamme, Katia M., Celedón, Juan C., Forno, Erick, Canino, Glorisa, Francis, Ben, Pirmohamed, Munir, Sinha, Ian, Hawcutt, Daniel B.
• Format: Article
• Language: English
• Subjects: 631/208/212/1728; 692/699/1785; Adolescent; Adult; Adverse and side effects; Anti-Asthmatic Agents - adverse effects; Asthma; Biomedical and Life Sciences; Biomedicine; Child; Child, Preschool; Drug therapy; Drug-Related Side Effects and Adverse Reactions - diagnosis; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - genetics; Drugs; Female; Gene Expression; Genetic aspects; Human Genetics; Humans; Male; Middle Aged; Oncology; Pharmacogenetics; Pharmacogenomic Testing; Pharmacogenomic Variants; Pharmacology, Experimental; Pharmacotherapy; Phenotype; Polymorphism, Single Nucleotide; Psychopharmacology; Review; Review Article; Risk Assessment; Risk Factors; Young Adult
• ISSN: 1470-269X; 1473-1150
• DOI: 10.1038/s41397-019-0140-y

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.