Trends in Degradable Mesoporous Organosilica-Based Nanomaterials for Controlling Drug Delivery: A Mini Review

The last few years of enhancing the design of hybrid mesoporous organosilica nanoparticleshas allowed their degradation under specific pathologic conditions, which finally is showing a lightin their potential use as drug delivery systems towards clinical trials. Nevertheless, the issueof controlling...

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Bibliographic Details
Published in:Materials 2020-08, Vol.13 (17), p.3668
Main Authors: Poscher, Vanessa, Salinas, Yolanda
Format: Article
Language:English
Subjects:
Alkoxysilanes
Bridges
Degradation
Design
Drug delivery systems
Drugs
Nanomaterials
Nanoparticles
Porous materials
Review
Silicon dioxide
Surfactants
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Summary:The last few years of enhancing the design of hybrid mesoporous organosilica nanoparticleshas allowed their degradation under specific pathologic conditions, which finally is showing a lightin their potential use as drug delivery systems towards clinical trials. Nevertheless, the issueof controlling the degradation on-demand at cellular level still remains a major challenge, even if ithas lately been addressed through the incorporation of degradable organo-bridged alkoxysilanesinto the silica framework. On this basis, this mini review covers some of the most recent examplesof dierent degradable organosilica nanomaterials with potential application in nanomedicine,from degradable non-porous to mesoporous organosilica nanoparticles (MONs), functionalized withresponsive molecular gates, and also the very promising degradable periodic mesoporous organosilicamaterials (PMOs) only consisting of organosilica bridges.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma13173668