Safety and Efficacy of Stem Cell Therapy in Patients With Ischemic Stroke

• Published in: Curēus (Palo Alto, CA) CA), 2020-08, Vol.12 (8), p.e9917-e9917
• Main Authors: Gautam, Jeevan, Alaref, Amer, Hassan, Abdallah, Sharma Kandel, Rajan, Mishra, Rohi, Jahan, Nusrat
• Format: Article
• Language: English
• Subjects: Neurology
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.9917

Stem cell therapy is emerging as a promising treatment strategy to treat patients with stroke. While there are established modes of treatment for stroke patients such as thrombolysis and endovascular intervention, most of the stroke patients frequently end up with major residual deficits or even death. The use of stem cells to treat stroke has been found to be beneficial in the animal models but strict evidence for the same in humans is still lacking. We reviewed 13 clinical trials of stem cell therapy in stroke patients conducted between 2014 and 2020 based on the search using the database PubMed, and the clinical trial registry (www.clinicaltrials.gov). We aimed to assess the safety and efficacy of stem cell treatment in stroke patients who participated in the trials. Quality assessment of the clinical trials revealed a sub-optimal score. We found mixed results regarding the efficacy of stem cells in the treatment of ischemic stroke although we could not do a quantitative analysis of the effect outcomes. Assessment for safety revealed promising results as there were only minor side effects related to cell therapy. Although stem cell therapy seems to be a promising strategy to treat stroke patients in the future, we concluded that the field needs more evidence regarding the safety and efficacy of the use of stem cells in stroke patients before we use them in the clinic.