Pancreatitis and Biliary Obstruction Secondary to Duodenal Metastasis from Rapidly Progressing Lung Adenocarcinoma Treated with Common Bile Duct Stenting

Non-small cell lung cancer (NSCLC) is characterised by diffuse metastases, with common sites being the brain, liver, bones, and adrenal glands. Small bowel metastasis from NSCLC is a rare phenomenon, particularly in patients with an adenocarcinoma histology. We report the case of a 56-year-old lung...

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Bibliographic Details
Published in:Case reports in oncology 2020-08, Vol.13 (2), p.962-967
Main Authors: O’Neill, Robert Sean, Duong, Tuan, Dionela, Welan, Rogge, Claudia, Brungs, Daniel
Format: Article
Language:English
Subjects:
Abdomen
Asymptomatic
Bile
Bile ducts
Biopsy
Case Report
Case reports
duodenum
Endoscopy
Hernias
imaging, pathology
Immunotherapy
Lung cancer
lung neoplasm
Lymphatic system
malignancy
Medical imaging
Medical prognosis
Metastasis
Monoclonal antibodies
Pancreatitis
Patients
Targeted cancer therapy
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Description
Summary:Non-small cell lung cancer (NSCLC) is characterised by diffuse metastases, with common sites being the brain, liver, bones, and adrenal glands. Small bowel metastasis from NSCLC is a rare phenomenon, particularly in patients with an adenocarcinoma histology. We report the case of a 56-year-old lung adenocarcinoma patient with a duodenal metastasis diagnosed on FDG/PET-CT and confirmed on duodenal biopsy. Although initially asymptomatic, he subsequently presented with obstructive jaundice secondary to rapid local disease progression at the duodenal metastasis, requiring endoscopic intervention for biliary drainage. He was commenced on single agent pembrolizumab, with disease response on subsequent follow-up. This case highlights a rare case of gastrointestinal metastasis from NSCLC requiring endoscopic intervention due to rapid progression of the disease at the site of metastasis.
ISSN:1662-6575
1662-6575
DOI:10.1159/000508745