The impact of subclinical congestion on the outcome of patients undergoing transcatheter aortic valve implantation

Background We investigated the impact of an elevated plasma volume status (PVS) in patients undergoing TAVI on early clinical safety and mortality and assessed the prognostic utility of PVS for outcome prediction. Materials and methods We retrospectively calculated the PVS in 652 patients undergoing...

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Bibliographic Details
Published in:European journal of clinical investigation 2020-08, Vol.50 (8), p.e13251-n/a
Main Authors: Adlbrecht, Christopher, Piringer, Felix, Resar, Jon, Watzal, Victoria, Andreas, Martin, Strouhal, Andreas, Hasan, Waseem, Geisler, Daniela, Weiss, Gabriel, Grabenwöger, Martin, Delle‐Karth, Georg, Mach, Markus
Format: Article
Language:English
Subjects:
Aorta
Aortic valve
Bleeding
cardiac decompensation
Congestion
Heart valves
Hematocrit
Implantation
Mathematical analysis
Original Paper
Original Papers
plasma volume
Safety
TAVR
transcatheter aortic valve implantation
Weight
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Summary:Background We investigated the impact of an elevated plasma volume status (PVS) in patients undergoing TAVI on early clinical safety and mortality and assessed the prognostic utility of PVS for outcome prediction. Materials and methods We retrospectively calculated the PVS in 652 patients undergoing TAVI between 2009 and 2018 at two centres. They were then categorized into two groups depending on their preoperative PVS (PVS ≤−4; n = 257 vs PVS>−4; n = 379). Relative PVS was derived by subtracting calculated ideal (iPVS = c × weight) from actual plasma volume (aPVS = (1 − haematocrit) × (a + (b × weight in kg)). Results The need for renal replacement therapy (1 (0.4%) vs 17 (4.5%); P = .001), re‐operation for noncardiac reasons (9 (3.5%) vs 32 (8.4%); P = .003), re‐operation for bleeding (9 (3.5%) vs 27 (7.1%); P = .037) and major bleeding (14 (5.4%) vs 37 (9.8%); P = .033) were significantly higher in patients with a PVS>−4. The composite 30‐day early safety endpoint (234 (91.1%) vs 314 (82.8%); P = .002) confirms that an increased preoperative PVS is associated with a worse overall outcome after TAVI. Conclusions An elevated PVS (>−4) as a marker for congestion is associated with significantly worse outcome after TAVI and therefore should be incorporated in preprocedural risk stratification.
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.13251