The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics

The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1...

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Bibliographic Details
Published in:Trends in Immunology 2020-11, Vol.41 (11), p.965-967
Main Authors: Woodruff, Trent M., Shukla, Arun K.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - immunology
Antibodies, Monoclonal - pharmacology
Betacoronavirus - drug effects
Betacoronavirus - immunology
Betacoronavirus - physiology
cellular signaling
Complement C5a - immunology
Complement C5a - metabolism
Complement component C5a
complement system
Coronavirus Infections - immunology
Coronavirus Infections - therapy
Coronavirus Infections - virology
Coronaviruses
COVID-19
Cytokines
Disease Models, Animal
drug discovery
G protein-coupled receptors
Global health
GPCRs
Humans
Infections
Inflammation
Laboratories
Lungs
Medical research
Mortality
Neutrophils
Pandemics
Pathology
Plasma
Pneumonia
Pneumonia, Viral - immunology
Pneumonia, Viral - therapy
Pneumonia, Viral - virology
Proteins
Public health
Receptor, Anaphylatoxin C5a - immunology
Receptor, Anaphylatoxin C5a - metabolism
Receptors, G-Protein-Coupled - immunology
Receptors, G-Protein-Coupled - metabolism
SARS-CoV-2
Sepsis
Severe acute respiratory syndrome coronavirus 2
Signal Transduction - drug effects
Signal Transduction - immunology
Spotlight
Tumor necrosis factor-TNF
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Description
Summary:The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy against COVID-19.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2020.09.008