Effect of Aqueous Extract of Adansonia digitata Stem Bark on the Development of Hypertension in L-NAME-Induced Hypertensive Rat Model

Background. Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats. Methods. The animals were administered L-NAME once daily f...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-10
Main Authors: Théophile, Dimo, Imar Djibrine, Soudy, Bekono Fouda, Yannick, Kemeta Azambou, David Romain, Atsamo, Albert Donatien, Bonabe, Christian, Ntchapda, Fidèle, Seke Etet, Paul F.
Format: Article
Language:English
Subjects:
Adansonia digitata
Animal models
Antihypertensives
Antioxidants
Aorta
Bark
Blood pressure
Cardiac muscle
Catalase
Cholesterol
Coronary vessels
Creatinine
Drug dosages
Folk medicine
Glutathione
Heart rate
Hemodynamics
Herbal medicine
High density lipoprotein
Hypertension
Inflammation
Kidneys
Laboratory animals
Low density lipoprotein
Malondialdehyde
Medicinal plants
NG-Nitroarginine methyl ester
Nitric oxide
Oxidative stress
Physiology
Transaminase
Triglycerides
Veins & arteries
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Summary:Background. Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats. Methods. The animals were administered L-NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with aqueous extract of A. digitata stem bark (100 and 200 mg/kg, p.o.) or captopril (20 mg/kg, p.o.). Then, hemodynamic and electrocardiographic parameters, oxidative stress markers, and the lipid profile were assessed in the blood and heart, aorta, and kidney homogenates, and histopathological analyses were performed. Results. L-NAME-induced hypertensive control animals, but not the animals concomitantly treated with A. digitata extract, displayed increases in the mean arterial blood pressure (21.64% difference, p
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/3678469