Effect of Aqueous Extract of Adansonia digitata Stem Bark on the Development of Hypertension in L-NAME-Induced Hypertensive Rat Model

Background. Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats. Methods. The animals were administered L-NAME once daily f...

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Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-10
Main Authors: Théophile, Dimo, Imar Djibrine, Soudy, Bekono Fouda, Yannick, Kemeta Azambou, David Romain, Atsamo, Albert Donatien, Bonabe, Christian, Ntchapda, Fidèle, Seke Etet, Paul F.
Format: Article
Language:English
Subjects:
Adansonia digitata
Animal models
Antihypertensives
Antioxidants
Aorta
Bark
Blood pressure
Cardiac muscle
Catalase
Cholesterol
Coronary vessels
Creatinine
Drug dosages
Folk medicine
Glutathione
Heart rate
Hemodynamics
Herbal medicine
High density lipoprotein
Hypertension
Inflammation
Kidneys
Laboratory animals
Low density lipoprotein
Malondialdehyde
Medicinal plants
NG-Nitroarginine methyl ester
Nitric oxide
Oxidative stress
Physiology
Transaminase
Triglycerides
Veins & arteries
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cited_by cdi_FETCH-LOGICAL-c471t-c751fdf41a51518e0f00fa9f4ea4096084a51d795c0caeb93f58126203ac7fb43
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creator Théophile, Dimo
Imar Djibrine, Soudy
Bekono Fouda, Yannick
Kemeta Azambou, David Romain
Atsamo, Albert Donatien
Bonabe, Christian
Ntchapda, Fidèle
Seke Etet, Paul F.
description Background. Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats. Methods. The animals were administered L-NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with aqueous extract of A. digitata stem bark (100 and 200 mg/kg, p.o.) or captopril (20 mg/kg, p.o.). Then, hemodynamic and electrocardiographic parameters, oxidative stress markers, and the lipid profile were assessed in the blood and heart, aorta, and kidney homogenates, and histopathological analyses were performed. Results. L-NAME-induced hypertensive control animals, but not the animals concomitantly treated with A. digitata extract, displayed increases in the mean arterial blood pressure (21.64% difference, p
doi_str_mv 10.1155/2020/3678469
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Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats. Methods. The animals were administered L-NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with aqueous extract of A. digitata stem bark (100 and 200 mg/kg, p.o.) or captopril (20 mg/kg, p.o.). Then, hemodynamic and electrocardiographic parameters, oxidative stress markers, and the lipid profile were assessed in the blood and heart, aorta, and kidney homogenates, and histopathological analyses were performed. Results. L-NAME-induced hypertensive control animals, but not the animals concomitantly treated with A. digitata extract, displayed increases in the mean arterial blood pressure (21.64% difference, p&lt;0.001, vs. dose 200 mg/kg), systolic arterial blood pressure (21.33%, p&lt;0.001), and the diastolic arterial blood pressure (21.84%, p&lt;0.001). In addition, hypertensive control animals displayed (i) increases in serum triglycerides, total cholesterol, LDL, and creatinine levels, malondialdehyde and transaminase activities, and atherogenic index; (ii) decreases in serum HDL, catalase, reduced glutathione, and nitric oxide; and (iii) aorta wall thickening, inflammatory cell infiltration, and cell loss in the cardiac muscle and renal tissues. As captopril, the extract prevented hypertension-like changes in lipid profile, cardiac, hepatic, and renal affection indicators, and oxidative stress markers. Conclusion. Our findings suggest that the extract of A. digitata has antihypertensive and antioxidant effects in L-NAME-induced hypertension rat models. These effects partly justify the traditional medicine use against cardiovascular disorders.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/3678469</identifier><identifier>PMID: 33014103</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adansonia digitata ; Animal models ; Antihypertensives ; Antioxidants ; Aorta ; Bark ; Blood pressure ; Cardiac muscle ; Catalase ; Cholesterol ; Coronary vessels ; Creatinine ; Drug dosages ; Folk medicine ; Glutathione ; Heart rate ; Hemodynamics ; Herbal medicine ; High density lipoprotein ; Hypertension ; Inflammation ; Kidneys ; Laboratory animals ; Low density lipoprotein ; Malondialdehyde ; Medicinal plants ; NG-Nitroarginine methyl ester ; Nitric oxide ; Oxidative stress ; Physiology ; Transaminase ; Triglycerides ; Veins &amp; arteries</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-10</ispartof><rights>Copyright © 2020 Fidèle Ntchapda et al.</rights><rights>Copyright © 2020 Fidèle Ntchapda et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats. Methods. The animals were administered L-NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with aqueous extract of A. digitata stem bark (100 and 200 mg/kg, p.o.) or captopril (20 mg/kg, p.o.). Then, hemodynamic and electrocardiographic parameters, oxidative stress markers, and the lipid profile were assessed in the blood and heart, aorta, and kidney homogenates, and histopathological analyses were performed. Results. L-NAME-induced hypertensive control animals, but not the animals concomitantly treated with A. digitata extract, displayed increases in the mean arterial blood pressure (21.64% difference, p&lt;0.001, vs. dose 200 mg/kg), systolic arterial blood pressure (21.33%, p&lt;0.001), and the diastolic arterial blood pressure (21.84%, p&lt;0.001). In addition, hypertensive control animals displayed (i) increases in serum triglycerides, total cholesterol, LDL, and creatinine levels, malondialdehyde and transaminase activities, and atherogenic index; (ii) decreases in serum HDL, catalase, reduced glutathione, and nitric oxide; and (iii) aorta wall thickening, inflammatory cell infiltration, and cell loss in the cardiac muscle and renal tissues. As captopril, the extract prevented hypertension-like changes in lipid profile, cardiac, hepatic, and renal affection indicators, and oxidative stress markers. Conclusion. Our findings suggest that the extract of A. digitata has antihypertensive and antioxidant effects in L-NAME-induced hypertension rat models. 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Imar Djibrine, Soudy ; Bekono Fouda, Yannick ; Kemeta Azambou, David Romain ; Atsamo, Albert Donatien ; Bonabe, Christian ; Ntchapda, Fidèle ; Seke Etet, Paul F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-c751fdf41a51518e0f00fa9f4ea4096084a51d795c0caeb93f58126203ac7fb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adansonia digitata</topic><topic>Animal models</topic><topic>Antihypertensives</topic><topic>Antioxidants</topic><topic>Aorta</topic><topic>Bark</topic><topic>Blood pressure</topic><topic>Cardiac muscle</topic><topic>Catalase</topic><topic>Cholesterol</topic><topic>Coronary vessels</topic><topic>Creatinine</topic><topic>Drug dosages</topic><topic>Folk medicine</topic><topic>Glutathione</topic><topic>Heart rate</topic><topic>Hemodynamics</topic><topic>Herbal medicine</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>Kidneys</topic><topic>Laboratory animals</topic><topic>Low density lipoprotein</topic><topic>Malondialdehyde</topic><topic>Medicinal plants</topic><topic>NG-Nitroarginine methyl ester</topic><topic>Nitric oxide</topic><topic>Oxidative stress</topic><topic>Physiology</topic><topic>Transaminase</topic><topic>Triglycerides</topic><topic>Veins &amp; 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Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats. Methods. The animals were administered L-NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with aqueous extract of A. digitata stem bark (100 and 200 mg/kg, p.o.) or captopril (20 mg/kg, p.o.). Then, hemodynamic and electrocardiographic parameters, oxidative stress markers, and the lipid profile were assessed in the blood and heart, aorta, and kidney homogenates, and histopathological analyses were performed. Results. L-NAME-induced hypertensive control animals, but not the animals concomitantly treated with A. digitata extract, displayed increases in the mean arterial blood pressure (21.64% difference, p&lt;0.001, vs. dose 200 mg/kg), systolic arterial blood pressure (21.33%, p&lt;0.001), and the diastolic arterial blood pressure (21.84%, p&lt;0.001). In addition, hypertensive control animals displayed (i) increases in serum triglycerides, total cholesterol, LDL, and creatinine levels, malondialdehyde and transaminase activities, and atherogenic index; (ii) decreases in serum HDL, catalase, reduced glutathione, and nitric oxide; and (iii) aorta wall thickening, inflammatory cell infiltration, and cell loss in the cardiac muscle and renal tissues. As captopril, the extract prevented hypertension-like changes in lipid profile, cardiac, hepatic, and renal affection indicators, and oxidative stress markers. Conclusion. Our findings suggest that the extract of A. digitata has antihypertensive and antioxidant effects in L-NAME-induced hypertension rat models. These effects partly justify the traditional medicine use against cardiovascular disorders.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>33014103</pmid><doi>10.1155/2020/3678469</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2242-8350</orcidid><orcidid>https://orcid.org/0000-0002-6788-0351</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adansonia digitata
Animal models
Antihypertensives
Antioxidants
Aorta
Bark
Blood pressure
Cardiac muscle
Catalase
Cholesterol
Coronary vessels
Creatinine
Drug dosages
Folk medicine
Glutathione
Heart rate
Hemodynamics
Herbal medicine
High density lipoprotein
Hypertension
Inflammation
Kidneys
Laboratory animals
Low density lipoprotein
Malondialdehyde
Medicinal plants
NG-Nitroarginine methyl ester
Nitric oxide
Oxidative stress
Physiology
Transaminase
Triglycerides
Veins & arteries
title Effect of Aqueous Extract of Adansonia digitata Stem Bark on the Development of Hypertension in L-NAME-Induced Hypertensive Rat Model
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