Quercetin Improving Lipid Metabolism by Regulating Lipid Metabolism Pathway of Ileum Mucosa in Broilers

This study is aimed at evaluating the regulatory mechanism of quercetin on lipid metabolism in the ileum of broilers to better understand these pathways decreasing abdominal fat. 480 chickens were randomly divided into 4 groups (control, 0.02% quercetin, 0.04% quercetin, and 0.06% quercetin). Breast...

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Published in:Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-17
Main Authors: Li, Yao, Lu, Han, Wang, Shanshan, Wang, Bo, Mao, Yanjun, Wang, Mi, Ying, Linlin
Format: Article
Language:English
Subjects:
Abdomen
Abdominal Fat - drug effects
Abdominal Fat - metabolism
Abdominal Fat - physiology
AMP-Activated Protein Kinases - metabolism
Animals
Bioengineering
Chickens
Diet
Dietary Supplements
Enzymes
Feeds
Gene expression
Gene Expression Regulation - drug effects
Gene Ontology
Glycerophospholipids - metabolism
Ileum - metabolism
Intestinal Mucosa - metabolism
Lipid Metabolism - drug effects
Lipid Metabolism - genetics
Lipids
Lipoproteins, HDL - blood
Metabolism
Muscle, Skeletal - drug effects
Muscle, Skeletal - physiology
Poultry
Quercetin - pharmacology
Signal Transduction - drug effects
Triglycerides - blood
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Summary:This study is aimed at evaluating the regulatory mechanism of quercetin on lipid metabolism in the ileum of broilers to better understand these pathways decreasing abdominal fat. 480 chickens were randomly divided into 4 groups (control, 0.02% quercetin, 0.04% quercetin, and 0.06% quercetin). Breast muscle, thigh muscle, and abdominal fat pad were removed and weighed at 42 d of age. Serum was obtained by centrifuging blood samples from the jugular vein (10 ml) to determine high-density lipoprotein (HDL), total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG), leptin, and adiponectin using ELISA. About 5 g of the ileum was harvested and immediately frozen in liquid nitrogen for RNA-seq. Then, the confirmation of RNA-seq results by the Real-Time Quantitative PCR (RT-qPCR) method was evaluated using Pearson’s correlation. Compared with control, abdominal fat percentage was significantly decreased with increasing quercetin supplementation, and the best result was obtained at 0.06% dietary quercetin supplementation (P
ISSN:1942-0900
1942-0994
DOI:10.1155/2020/8686248