Epigenetic basis of Alzheimer disease

Alzheimer disease (AD) is the primary form of dementia that occurs spontaneously in older adults. Interestingly, the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD. In this re...

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Bibliographic Details
Published in:World journal of biological chemistry 2020-09, Vol.11 (2), p.62-75
Main Authors: Tecalco-Cruz, Angeles C, Ramírez-Jarquín, Josué O, Alvarez-Sánchez, María E, Zepeda-Cervantes, Jesus
Format: Article
Language:English
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Summary:Alzheimer disease (AD) is the primary form of dementia that occurs spontaneously in older adults. Interestingly, the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD. In this review, we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD. The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD.
ISSN:1949-8454
1949-8454
DOI:10.4331/wjbc.v11.i2.62