Superparamagnetic iron oxide nanoparticles promote ferroptosis of ischemic cardiomyocytes

Notably, overexpression of ABCB8 in cardiomyocytes in mice reduces mitochondrial iron and protects against I/R damage, 30 suggesting that ABCB8 might play an important role in maintaining iron homeostasis in myocardial mitochondria and regulating ferroptosis after I/R injury. [...]it is not difficul...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2020-09, Vol.24 (18), p.11030-11033
Main Authors: Zheng, Hao, You, Jieyun, Yao, Xiaobo, Lu, Qizheng, Guo, Wei, Shen, Yunli
Format: Article
Language:English
Subjects:
Animal models
Apoptosis
Autophagy
Cardiomyocytes
Cardiotoxicity
Conflicts of interest
Experiments
Ferroptosis
Homeostasis
Hypotheses
Iron
Iron oxides
Ischemia
Letter to the Editor
Lipid metabolism
Lipid peroxidation
Lipids
Metabolism
Mitochondria
Morphology
Myocardial ischemia
Myocardium
Nanoparticles
Oxidative stress
Phagocytosis
Reperfusion
superparamagnetic iron oxide nanoparticles
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Summary:Notably, overexpression of ABCB8 in cardiomyocytes in mice reduces mitochondrial iron and protects against I/R damage, 30 suggesting that ABCB8 might play an important role in maintaining iron homeostasis in myocardial mitochondria and regulating ferroptosis after I/R injury. [...]it is not difficult to speculate that SPION could aggravate mitochondrial iron load in I/R myocardium. [...]the mitochondrial iron metabolism, lipid peroxidation, morphology and function of mitochondria and ferroptosis should be carefully detected after SPION injected into the peri‐infarcted zones of myocardial ischemia‐reperfusion rats. [...]the rat models of myocardial ischemia‐reperfusion were randomly divided into different groups to, respectively, treated with apoptosis inhibitor, necrosis inhibitor, autophagy inhibitor and ferroptosis inhibitor, in order to verify whether ferroptosis play a pivotal role in cardiomyocytes death induced by SPION.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.15722