BMP2 signalling activation enhances bone metastases of non‐small cell lung cancer

Distant metastases occur when non‐small cell lung cancer (NSCLC) is at late stages. Bone metastasis is one of the most frequent metastases of NSCLC and leads to poor prognosis. It has been reported that high expression of BMP2 in NSCLC correlates with poor survival, but whether BMP2 contributes to N...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular and molecular medicine 2020-09, Vol.24 (18), p.10768-10784
Main Authors: Huang, Fei, Cao, Yaqiang, Wu, Gui, Chen, Junying, CaihongWang, Lin, Wanzun, Lan, Ruilong, Wu, Bing, Xie, Xianhe, Hong, Jinsheng, Fu, Lengxi
Format: Article
Language:English
Subjects:
Alcohol
Antibodies
BMP2 signalling
bone metastases
Bone morphogenetic protein 2
Bone tumors
Bones
Carbon dioxide
Cell adhesion & migration
Cell culture
Fibroblasts
Leukocyte migration
Lung cancer
Lung carcinoma
Macrophages
Medical prognosis
Metastases
Metastasis
Non-small cell lung carcinoma
NSCLC
Original
osteoblastic mechanism
Osteoblastogenesis
Osteoblasts
Osteoclastogenesis
Osteoclasts
Osteolysis
osteolytic mechanism
Pore size
Prostate cancer
Small cell lung carcinoma
Stroma
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Distant metastases occur when non‐small cell lung cancer (NSCLC) is at late stages. Bone metastasis is one of the most frequent metastases of NSCLC and leads to poor prognosis. It has been reported that high expression of BMP2 in NSCLC correlates with poor survival, but whether BMP2 contributes to NSCLC bone metastasis remains largely unknown. The activation of BMP signalling is found in metastatic bone tumours of mice Lewis lung carcinoma and predicts poor survival in human NSCLC. BMP2 signalling activation can enhance bone metastasis of Lewis lung carcinoma. Moreover, BMP2 secreted by stroma fibroblasts can promote the migration and invasion of NSCLC cells. Besides, in combination with pre‐osteoblast and LLCs, BMP2 could enhance the differentiation of macrophages into osteoclasts to play roles in the osteolytic mechanism of NSCLC bone metastasis. Interestingly, NSCLC cells can also enrich BMP2 to pre‐osteoblasts to function in the osteoblastic mechanism. Our results firstly demonstrate the detailed mechanisms about what roles BMP2 signalling play in enhancing NSCLC bone metastases. These findings provide a new potential therapy choice for preventing bone metastases of NSCLC via the inhibition of BMP2 signalling.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.15702