Breast cancer biomarker detection through the photoluminescence of epitaxial monolayer MoS2 flakes

In this work we report on the characterization and biological functionalization of 2D MoS 2 flakes, epitaxially grown on sapphire, to develop an optical biosensor for the breast cancer biomarker miRNA21. The MoS 2 flakes were modified with a thiolated DNA probe complementary to the target biomarker....

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2020-09, Vol.10 (1), p.16039-16039, Article 16039
Main Authors: Catalán-Gómez, Sergio, Briones, María, Cortijo-Campos, Sandra, García-Mendiola, Tania, de Andrés, Alicia, Garg, Sourav, Kung, Patrick, Lorenzo, Encarnación, Pau, Jose Luis, Redondo-Cubero, Andrés
Format: Article
Language:English
Subjects:
631/67/1347
639/301
639/301/357
639/624/399/54/992
692/53
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work we report on the characterization and biological functionalization of 2D MoS 2 flakes, epitaxially grown on sapphire, to develop an optical biosensor for the breast cancer biomarker miRNA21. The MoS 2 flakes were modified with a thiolated DNA probe complementary to the target biomarker. Based on the photoluminescence of MoS 2 , the hybridization events were analyzed for the target (miRNA21c) and the control non-complementary sequence (miRNA21nc). A specific redshift was observed for the hybridization with miRNA21c, but not for the control, demonstrating the biomarker recognition via PL. The homogeneity of these MoS 2 platforms was verified with microscopic maps. The detailed spectroscopic analysis of the spectra reveals changes in the trion to excitation ratio, being the redshift after the hybridization ascribed to both peaks. The results demonstrate the benefits of optical biosensors based on MoS 2 monolayer for future commercial devices.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-73029-9