Salvage chemotherapy with taxane and platinum for women with recurrent uterine carcinosarcoma

To examine survival after recurrence (SAR) among women with recurrent uterine carcinosarcoma who received a taxane/platinum doublet as the first-line salvage chemotherapy. We retrospectively examined 148 women with recurrent uterine carcinosarcoma who received salvage chemotherapy within a cohort of...

Full description

Saved in:
Bibliographic Details
Published in:Gynecologic oncology 2017-12, Vol.147 (3), p.565-571
Main Authors: Matsuo, Koji, Ross, Malcolm S., Yunokawa, Mayu, Johnson, Marian S., Machida, Hiroko, Omatsu, Kohei, Klobocista, Merieme M., Im, Dwight D., Satoh, Shinya, Baba, Tsukasa, Ikeda, Yuji, Bush, Stephen H., Hasegawa, Kosei, Blake, Erin A., Takekuma, Munetaka, Shida, Masako, Nishimura, Masato, Adachi, Sosuke, Pejovic, Tanja, Takeuchi, Satoshi, Yokoyama, Takuhei, Ueda, Yutaka, Iwasaki, Keita, Miyake, Takahito M., Yanai, Shiori, Nagano, Tadayoshi, Takano, Tadao, Shahzad, Mian M.K., Ueland, Frederick R., Kelley, Joseph L., Roman, Lynda D.
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bridged-Ring Compounds - administration & dosage
Carcinosarcoma - drug therapy
Carcinosarcoma - mortality
Chemotherapy
Cohort Studies
Female
Humans
Japan - epidemiology
Middle Aged
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - mortality
Organoplatinum Compounds - administration & dosage
Platinum
Recurrence
Retrospective Studies
Salvage Therapy
Survival outcome
Taxane
Taxoids - administration & dosage
United States - epidemiology
Uterine carcinosarcoma
Uterine Neoplasms - drug therapy
Uterine Neoplasms - mortality
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To examine survival after recurrence (SAR) among women with recurrent uterine carcinosarcoma who received a taxane/platinum doublet as the first-line salvage chemotherapy. We retrospectively examined 148 women with recurrent uterine carcinosarcoma who received salvage chemotherapy within a cohort of 906 uterine carcinosarcomas. An independent association of salvage chemotherapy type and SAR was examined with multivariate analysis. There were 71 (48.0%) women who received a taxane/platinum regimen. On univariate analysis, women who received a taxane/platinum doublet had a higher 2-year SAR rate compared to women who received non-taxane/platinum regimens (55.5% versus 34.8%, P
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2017.10.008