Characterizing sarcoma dominance pattern in uterine carcinosarcoma: Homologous versus heterologous element

• Published in: Surgical oncology 2018-09, Vol.27 (3), p.433-440
• Main Authors: Matsuo, Koji, Takazawa, Yutaka, Ross, Malcolm S., Elishaev, Esther, Yunokawa, Mayu, Sheridan, Todd B., Bush, Stephen H., Klobocista, Merieme M., Blake, Erin A., Takano, Tadao, Baba, Tsukasa, Satoh, Shinya, Shida, Masako, Ikeda, Yuji, Adachi, Sosuke, Yokoyama, Takuhei, Takekuma, Munetaka, Yanai, Shiori, Takeuchi, Satoshi, Nishimura, Masato, Iwasaki, Keita, Johnson, Marian S., Yoshida, Masayuki, Hakam, Ardeshir, Machida, Hiroko, Mhawech-Fauceglia, Paulette, Ueda, Yutaka, Yoshino, Kiyoshi, Kajiwara, Hiroshi, Hasegawa, Kosei, Yasuda, Masanori, Miyake, Takahito M., Moriya, Takuya, Yuba, Yoshiaki, Morgan, Terry, Fukagawa, Tomoyuki, Pejovic, Tanja, Nagano, Tadayoshi, Sasaki, Takeshi, Richmond, Abby M., Post, Miriam D., Shahzad, Mian M.K., Im, Dwight D., Yoshida, Hiroshi, Omatsu, Kohei, Ueland, Frederick R., Kelley, Joseph L., Karabakhtsian, Rouzan G., Roman, Lynda D.
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Clear Cell - pathology; Adenocarcinoma, Clear Cell - surgery; Biology; Carcinosarcoma - pathology; Carcinosarcoma - surgery; Chemotherapy; Cystadenocarcinoma, Serous - pathology; Cystadenocarcinoma, Serous - surgery; Demographics; Dominance; Endometrial cancer; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Female; Follow-Up Studies; Heterologous; Histopathology; Homologous; Homology; Humans; Lymphatic system; Medical prognosis; Metastases; Middle Aged; Multivariate analysis; Myometrium; Prognosis; Radiation therapy; Retrospective Studies; Sarcoma; Sarcoma dominance; Secondary analysis; Surgery; Survival; Survival Rate; Tumors; Uterine cancer; Uterine carcinosarcoma; Uterine Neoplasms - pathology; Uterine Neoplasms - surgery; Uterus
• ISSN: 0960-7404; 1879-3320; 1879-3320
• DOI: 10.1016/j.suronc.2018.05.017

To examine significance of sarcoma dominance (SD) patterns in uterine carcinosarcoma (UCS). This is a secondary analysis of multicenter retrospective study examining women with stages I-IV UCS who underwent primary surgery. SD was defined as >50% of sarcoma component in uterine tumor. SD patterns were grouped as homologous sarcoma without SD (homo/non-dominance, n = 351), heterologous sarcoma without SD (hetero/non-dominance, n = 174), homologous sarcoma with SD (homo/dominance, n = 175), and heterologous sarcoma with SD (hetero/dominance, n = 189), and correlated to tumor characteristics and survival. SD patterns were significantly associated with age, body habitus, carcinoma type, tumor size, depth of myometrial invasion, and nodal metastasis (all, P