Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training

Abstract Context Exercise training improves bone mineral density, but little is known about the effects of training on bone marrow (BM) metabolism. BM insulin sensitivity has been suggested to play an important role in bone health and whole-body insulin sensitivity. Objective To study the effects of...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2020-12, Vol.105 (12), p.1-e4303
Main Authors: Ojala, Ronja, Motiani, Kumail K, Ivaska, Kaisa K, Arponen, Milja, Eskelinen, Jari-Joonas, Virtanen, Kirsi A, Löyttyniemi, Eliisa, Heiskanen, Marja A, U-Din, Mueez, Nuutila, Pirjo, Kalliokoski, Kari K, Hannukainen, Jarna C
Format: Article
Language:English
Subjects:
Adult
Bone marrow
Bone Marrow - metabolism
Bone mineral density
Bone turnover
Clinical s
Exercise
Exercise - physiology
Female
Femur
Fitness training programs
Health aspects
Humans
Insulin
Insulin resistance
Insulin Resistance - physiology
Male
Males
Metabolism
Middle Aged
Osteocalcin
Physical training
Physiological aspects
Positron emission tomography
Sedentary Behavior
Thorax
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Summary:Abstract Context Exercise training improves bone mineral density, but little is known about the effects of training on bone marrow (BM) metabolism. BM insulin sensitivity has been suggested to play an important role in bone health and whole-body insulin sensitivity. Objective To study the effects of exercise training on BM metabolism. Design Randomized controlled trial. Setting Clinical research center. Participants Sedentary healthy (n = 28, 40–55 years, all males) and insulin resistant (IR) subjects (n = 26, 43–55 years, males/females 16/10) Intervention Two weeks of sprint interval training or moderate-intensity continuous training Main outcome measures We measured femoral, lumbar, and thoracic BM insulin-stimulated glucose uptake (GU) and fasting free fatty acid uptake (FFAU) using positron-emission tomography and bone turnover markers from plasma. Results At baseline, GU was highest in lumbar, followed by thoracic, and lowest in femoral BM (all Ps 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgaa516