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Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training
Abstract Context Exercise training improves bone mineral density, but little is known about the effects of training on bone marrow (BM) metabolism. BM insulin sensitivity has been suggested to play an important role in bone health and whole-body insulin sensitivity. Objective To study the effects of...
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| Published in: | The journal of clinical endocrinology and metabolism 2020-12, Vol.105 (12), p.1-e4303 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Ojala, Ronja Motiani, Kumail K Ivaska, Kaisa K Arponen, Milja Eskelinen, Jari-Joonas Virtanen, Kirsi A Löyttyniemi, Eliisa Heiskanen, Marja A U-Din, Mueez Nuutila, Pirjo Kalliokoski, Kari K Hannukainen, Jarna C |
| description | Abstract
Context
Exercise training improves bone mineral density, but little is known about the effects of training on bone marrow (BM) metabolism. BM insulin sensitivity has been suggested to play an important role in bone health and whole-body insulin sensitivity.
Objective
To study the effects of exercise training on BM metabolism.
Design
Randomized controlled trial.
Setting
Clinical research center.
Participants
Sedentary healthy (n = 28, 40–55 years, all males) and insulin resistant (IR) subjects (n = 26, 43–55 years, males/females 16/10)
Intervention
Two weeks of sprint interval training or moderate-intensity continuous training
Main outcome measures
We measured femoral, lumbar, and thoracic BM insulin-stimulated glucose uptake (GU) and fasting free fatty acid uptake (FFAU) using positron-emission tomography and bone turnover markers from plasma.
Results
At baseline, GU was highest in lumbar, followed by thoracic, and lowest in femoral BM (all Ps |
| doi_str_mv | 10.1210/clinem/dgaa516 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7526736</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A659834627</galeid><oup_id>10.1210/clinem/dgaa516</oup_id><sourcerecordid>A659834627</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-e5aca52ba248a9f4747ce4d5dc0cab79ceba2363d37f2c266c664528b0f3f16c3</originalsourceid><addsrcrecordid>eNqFkt9rFDEQx4Mo9nr66qMEfNGHbfM7uy_CWaoetAhSwRcJ2ezsmbKbnMlutf-9Oe6sPyjIPARmPvMdZvJF6BklJ5RRcuoGH2A87TbWSqoeoAVthKw0bfRDtCCE0arR7PMROs75mhAqhOSP0RFnupZKigX68iYGwJc2pfgdX8Jk2zj4POJ1xutxa32CDvuA1yHPZRL-CNnnyQYH2IZuh6R4Axmv-gkSPv8ByfkM-CpZH3zYPEGPejtkeHp4l-jT2_Ors_fVxYd367PVReUkbaYKpHVWstYyUdumF1poB6KTnSPOtrpxUEpc8Y7rnjmmlFNKSFa3pOc9VY4v0eu97nZuR-gchCnZwWyTH226NdF683cl-K9mE2-MlkzporxELw8CKX6bIU9m9NnBMNgAcc6GCS6ILDdrCvriH_Q6zimU9QqlKWENr_VvamMHMD70scx1O1GzUrKpuVBsR53cQ5XoYPSu_EzvS_6-Bpdizgn6ux0pMTtDmL0hzMEQpeH5n5e5w385oACv9kCct_8T-wnsnsGs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471029387</pqid></control><display><type>article</type><title>Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training</title><source>Oxford Journals Online</source><creator>Ojala, Ronja ; Motiani, Kumail K ; Ivaska, Kaisa K ; Arponen, Milja ; Eskelinen, Jari-Joonas ; Virtanen, Kirsi A ; Löyttyniemi, Eliisa ; Heiskanen, Marja A ; U-Din, Mueez ; Nuutila, Pirjo ; Kalliokoski, Kari K ; Hannukainen, Jarna C</creator><creatorcontrib>Ojala, Ronja ; Motiani, Kumail K ; Ivaska, Kaisa K ; Arponen, Milja ; Eskelinen, Jari-Joonas ; Virtanen, Kirsi A ; Löyttyniemi, Eliisa ; Heiskanen, Marja A ; U-Din, Mueez ; Nuutila, Pirjo ; Kalliokoski, Kari K ; Hannukainen, Jarna C</creatorcontrib><description>Abstract
Context
Exercise training improves bone mineral density, but little is known about the effects of training on bone marrow (BM) metabolism. BM insulin sensitivity has been suggested to play an important role in bone health and whole-body insulin sensitivity.
Objective
To study the effects of exercise training on BM metabolism.
Design
Randomized controlled trial.
Setting
Clinical research center.
Participants
Sedentary healthy (n = 28, 40–55 years, all males) and insulin resistant (IR) subjects (n = 26, 43–55 years, males/females 16/10)
Intervention
Two weeks of sprint interval training or moderate-intensity continuous training
Main outcome measures
We measured femoral, lumbar, and thoracic BM insulin-stimulated glucose uptake (GU) and fasting free fatty acid uptake (FFAU) using positron-emission tomography and bone turnover markers from plasma.
Results
At baseline, GU was highest in lumbar, followed by thoracic, and lowest in femoral BM (all Ps < 0.0001). FFAU was higher in lumbar and thoracic than femoral BM (both Ps < 0.0001). BM FFAU and femoral BM GU were higher in healthy compared to IR men and in females compared to males (all Ps < 0.05). Training increased femoral BM GU similarly in all groups and decreased lumbar BM FFAU in males (all Ps < 0.05). Osteocalcin and PINP were lower in IR than healthy men and correlated positively with femoral BM GU and glycemic status (all Ps < 0.05).
Conclusions
BM metabolism differs regarding anatomical location. Short-term training improves BM GU and FFAU in healthy and IR subjects. Bone turnover rate is decreased in insulin resistance and associates positively with BM metabolism and glycemic control.
Clinical Trial Registration Number
NCT01344928.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/clinem/dgaa516</identifier><identifier>PMID: 32785654</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Bone marrow ; Bone Marrow - metabolism ; Bone mineral density ; Bone turnover ; Clinical s ; Exercise ; Exercise - physiology ; Female ; Femur ; Fitness training programs ; Health aspects ; Humans ; Insulin ; Insulin resistance ; Insulin Resistance - physiology ; Male ; Males ; Metabolism ; Middle Aged ; Osteocalcin ; Physical training ; Physiological aspects ; Positron emission tomography ; Sedentary Behavior ; Thorax</subject><ispartof>The journal of clinical endocrinology and metabolism, 2020-12, Vol.105 (12), p.1-e4303</ispartof><rights>Endocrine Society 2020. 2020</rights><rights>Endocrine Society 2020.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-e5aca52ba248a9f4747ce4d5dc0cab79ceba2363d37f2c266c664528b0f3f16c3</citedby><cites>FETCH-LOGICAL-c519t-e5aca52ba248a9f4747ce4d5dc0cab79ceba2363d37f2c266c664528b0f3f16c3</cites><orcidid>0000-0002-8692-4049 ; 0000-0002-2393-0281 ; 0000-0001-9597-338X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32785654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ojala, Ronja</creatorcontrib><creatorcontrib>Motiani, Kumail K</creatorcontrib><creatorcontrib>Ivaska, Kaisa K</creatorcontrib><creatorcontrib>Arponen, Milja</creatorcontrib><creatorcontrib>Eskelinen, Jari-Joonas</creatorcontrib><creatorcontrib>Virtanen, Kirsi A</creatorcontrib><creatorcontrib>Löyttyniemi, Eliisa</creatorcontrib><creatorcontrib>Heiskanen, Marja A</creatorcontrib><creatorcontrib>U-Din, Mueez</creatorcontrib><creatorcontrib>Nuutila, Pirjo</creatorcontrib><creatorcontrib>Kalliokoski, Kari K</creatorcontrib><creatorcontrib>Hannukainen, Jarna C</creatorcontrib><title>Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Context
Exercise training improves bone mineral density, but little is known about the effects of training on bone marrow (BM) metabolism. BM insulin sensitivity has been suggested to play an important role in bone health and whole-body insulin sensitivity.
Objective
To study the effects of exercise training on BM metabolism.
Design
Randomized controlled trial.
Setting
Clinical research center.
Participants
Sedentary healthy (n = 28, 40–55 years, all males) and insulin resistant (IR) subjects (n = 26, 43–55 years, males/females 16/10)
Intervention
Two weeks of sprint interval training or moderate-intensity continuous training
Main outcome measures
We measured femoral, lumbar, and thoracic BM insulin-stimulated glucose uptake (GU) and fasting free fatty acid uptake (FFAU) using positron-emission tomography and bone turnover markers from plasma.
Results
At baseline, GU was highest in lumbar, followed by thoracic, and lowest in femoral BM (all Ps < 0.0001). FFAU was higher in lumbar and thoracic than femoral BM (both Ps < 0.0001). BM FFAU and femoral BM GU were higher in healthy compared to IR men and in females compared to males (all Ps < 0.05). Training increased femoral BM GU similarly in all groups and decreased lumbar BM FFAU in males (all Ps < 0.05). Osteocalcin and PINP were lower in IR than healthy men and correlated positively with femoral BM GU and glycemic status (all Ps < 0.05).
Conclusions
BM metabolism differs regarding anatomical location. Short-term training improves BM GU and FFAU in healthy and IR subjects. Bone turnover rate is decreased in insulin resistance and associates positively with BM metabolism and glycemic control.
Clinical Trial Registration Number
NCT01344928.</description><subject>Adult</subject><subject>Bone marrow</subject><subject>Bone Marrow - metabolism</subject><subject>Bone mineral density</subject><subject>Bone turnover</subject><subject>Clinical s</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Femur</subject><subject>Fitness training programs</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Males</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Osteocalcin</subject><subject>Physical training</subject><subject>Physiological aspects</subject><subject>Positron emission tomography</subject><subject>Sedentary Behavior</subject><subject>Thorax</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqFkt9rFDEQx4Mo9nr66qMEfNGHbfM7uy_CWaoetAhSwRcJ2ezsmbKbnMlutf-9Oe6sPyjIPARmPvMdZvJF6BklJ5RRcuoGH2A87TbWSqoeoAVthKw0bfRDtCCE0arR7PMROs75mhAqhOSP0RFnupZKigX68iYGwJc2pfgdX8Jk2zj4POJ1xutxa32CDvuA1yHPZRL-CNnnyQYH2IZuh6R4Axmv-gkSPv8ByfkM-CpZH3zYPEGPejtkeHp4l-jT2_Ors_fVxYd367PVReUkbaYKpHVWstYyUdumF1poB6KTnSPOtrpxUEpc8Y7rnjmmlFNKSFa3pOc9VY4v0eu97nZuR-gchCnZwWyTH226NdF683cl-K9mE2-MlkzporxELw8CKX6bIU9m9NnBMNgAcc6GCS6ILDdrCvriH_Q6zimU9QqlKWENr_VvamMHMD70scx1O1GzUrKpuVBsR53cQ5XoYPSu_EzvS_6-Bpdizgn6ux0pMTtDmL0hzMEQpeH5n5e5w385oACv9kCct_8T-wnsnsGs</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Ojala, Ronja</creator><creator>Motiani, Kumail K</creator><creator>Ivaska, Kaisa K</creator><creator>Arponen, Milja</creator><creator>Eskelinen, Jari-Joonas</creator><creator>Virtanen, Kirsi A</creator><creator>Löyttyniemi, Eliisa</creator><creator>Heiskanen, Marja A</creator><creator>U-Din, Mueez</creator><creator>Nuutila, Pirjo</creator><creator>Kalliokoski, Kari K</creator><creator>Hannukainen, Jarna C</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8692-4049</orcidid><orcidid>https://orcid.org/0000-0002-2393-0281</orcidid><orcidid>https://orcid.org/0000-0001-9597-338X</orcidid></search><sort><creationdate>20201201</creationdate><title>Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training</title><author>Ojala, Ronja ; Motiani, Kumail K ; Ivaska, Kaisa K ; Arponen, Milja ; Eskelinen, Jari-Joonas ; Virtanen, Kirsi A ; Löyttyniemi, Eliisa ; Heiskanen, Marja A ; U-Din, Mueez ; Nuutila, Pirjo ; Kalliokoski, Kari K ; Hannukainen, Jarna C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-e5aca52ba248a9f4747ce4d5dc0cab79ceba2363d37f2c266c664528b0f3f16c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Bone marrow</topic><topic>Bone Marrow - metabolism</topic><topic>Bone mineral density</topic><topic>Bone turnover</topic><topic>Clinical s</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Femur</topic><topic>Fitness training programs</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Males</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Osteocalcin</topic><topic>Physical training</topic><topic>Physiological aspects</topic><topic>Positron emission tomography</topic><topic>Sedentary Behavior</topic><topic>Thorax</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ojala, Ronja</creatorcontrib><creatorcontrib>Motiani, Kumail K</creatorcontrib><creatorcontrib>Ivaska, Kaisa K</creatorcontrib><creatorcontrib>Arponen, Milja</creatorcontrib><creatorcontrib>Eskelinen, Jari-Joonas</creatorcontrib><creatorcontrib>Virtanen, Kirsi A</creatorcontrib><creatorcontrib>Löyttyniemi, Eliisa</creatorcontrib><creatorcontrib>Heiskanen, Marja A</creatorcontrib><creatorcontrib>U-Din, Mueez</creatorcontrib><creatorcontrib>Nuutila, Pirjo</creatorcontrib><creatorcontrib>Kalliokoski, Kari K</creatorcontrib><creatorcontrib>Hannukainen, Jarna C</creatorcontrib><collection>Open Access: Oxford University Press Open Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ojala, Ronja</au><au>Motiani, Kumail K</au><au>Ivaska, Kaisa K</au><au>Arponen, Milja</au><au>Eskelinen, Jari-Joonas</au><au>Virtanen, Kirsi A</au><au>Löyttyniemi, Eliisa</au><au>Heiskanen, Marja A</au><au>U-Din, Mueez</au><au>Nuutila, Pirjo</au><au>Kalliokoski, Kari K</au><au>Hannukainen, Jarna C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>105</volume><issue>12</issue><spage>1</spage><epage>e4303</epage><pages>1-e4303</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Context
Exercise training improves bone mineral density, but little is known about the effects of training on bone marrow (BM) metabolism. BM insulin sensitivity has been suggested to play an important role in bone health and whole-body insulin sensitivity.
Objective
To study the effects of exercise training on BM metabolism.
Design
Randomized controlled trial.
Setting
Clinical research center.
Participants
Sedentary healthy (n = 28, 40–55 years, all males) and insulin resistant (IR) subjects (n = 26, 43–55 years, males/females 16/10)
Intervention
Two weeks of sprint interval training or moderate-intensity continuous training
Main outcome measures
We measured femoral, lumbar, and thoracic BM insulin-stimulated glucose uptake (GU) and fasting free fatty acid uptake (FFAU) using positron-emission tomography and bone turnover markers from plasma.
Results
At baseline, GU was highest in lumbar, followed by thoracic, and lowest in femoral BM (all Ps < 0.0001). FFAU was higher in lumbar and thoracic than femoral BM (both Ps < 0.0001). BM FFAU and femoral BM GU were higher in healthy compared to IR men and in females compared to males (all Ps < 0.05). Training increased femoral BM GU similarly in all groups and decreased lumbar BM FFAU in males (all Ps < 0.05). Osteocalcin and PINP were lower in IR than healthy men and correlated positively with femoral BM GU and glycemic status (all Ps < 0.05).
Conclusions
BM metabolism differs regarding anatomical location. Short-term training improves BM GU and FFAU in healthy and IR subjects. Bone turnover rate is decreased in insulin resistance and associates positively with BM metabolism and glycemic control.
Clinical Trial Registration Number
NCT01344928.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32785654</pmid><doi>10.1210/clinem/dgaa516</doi><orcidid>https://orcid.org/0000-0002-8692-4049</orcidid><orcidid>https://orcid.org/0000-0002-2393-0281</orcidid><orcidid>https://orcid.org/0000-0001-9597-338X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2020-12, Vol.105 (12), p.1-e4303 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7526736 |
| source | Oxford Journals Online |
| subjects | Adult Bone marrow Bone Marrow - metabolism Bone mineral density Bone turnover Clinical s Exercise Exercise - physiology Female Femur Fitness training programs Health aspects Humans Insulin Insulin resistance Insulin Resistance - physiology Male Males Metabolism Middle Aged Osteocalcin Physical training Physiological aspects Positron emission tomography Sedentary Behavior Thorax |
| title | Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training |
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