Intermittent but not continuous access to cocaine produces individual variability in addiction susceptibility in rats

Drug addiction is a chronic disease defined by a complex set of characteristics, including loss of control over drug intake and persistent drug craving, which primarily affects a small percentage of people who try drugs. Although many models have been developed to study individual aspects of drug us...

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Bibliographic Details
Published in:Psychopharmacology 2020-10, Vol.237 (10), p.2929-2941
Main Authors: Garcia, A. F., Webb, I. G., Yager, L. M., Seo, M. B., Ferguson, S. M.
Format: Article
Language:English
Subjects:
Addictions
Animal models
Animals
Behavior, Addictive - psychology
Biomedical and Life Sciences
Biomedicine
Calcium (intracellular)
Calcium signalling
Chronic diseases
Chronic illnesses
Cocaine
Cocaine - administration & dosage
Cocaine - toxicity
Cocaine-Related Disorders - psychology
Corpus Striatum - drug effects
Corpus Striatum - physiology
Disease susceptibility
Dopamine Uptake Inhibitors - administration & dosage
Dopamine Uptake Inhibitors - toxicity
Drug addiction
Drug self-administration
Drug use
Drug-Seeking Behavior - drug effects
Drug-Seeking Behavior - physiology
Intracellular signalling
Locomotion - drug effects
Locomotion - physiology
Male
Neostriatum
Neurosciences
Original Investigation
Pharmacology/Toxicology
Psychiatry
Rats
Rats, Sprague-Dawley
Reinstatement
Self Administration
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Summary:Drug addiction is a chronic disease defined by a complex set of characteristics, including loss of control over drug intake and persistent drug craving, which primarily affects a small percentage of people who try drugs. Although many models have been developed to study individual aspects of drug use, there is great translational value in having an animal model that encompasses multiple aspects of the human disease, including the variation in severity observed in humans. Here, we describe an intermittent access model of cocaine self-administration that produces a subset of rats that display many of the core features of addiction, including escalation of drug intake, a binge-like pattern of drug use, robust locomotor sensitization, and high levels of drug-seeking during cue-induced reinstatement. This group is compared with rats that have the same drug history but do not develop this pattern of drug-taking and drug-seeking, as well as rats that undergo a traditional continuous access paradigm. Finally, we observe that high levels of cocaine consumption produce long-term changes in intracellular calcium signaling in the dorsomedial striatum.
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-020-05581-1