Caffeine intake and cognitive functions in children

• Published in: Psychopharmacology 2020-10, Vol.237 (10), p.3109-3116
• Main Authors: Zhang, Han, Lee, Zu Xuan, Qiu, Anqi
• Format: Article
• Language: English
• Subjects: Adolescent; Beverages; Beverages - adverse effects; Biomedical and Life Sciences; Biomedicine; Caffeine; Caffeine - administration & dosage; Caffeine - adverse effects; Central Nervous System Stimulants - administration & dosage; Central Nervous System Stimulants - adverse effects; Child; Children; Cognition - drug effects; Cognition - physiology; Cognitive ability; Cognitive development; Cohort Studies; Comprehension - drug effects; Comprehension - physiology; Drugs and youth; Female; Humans; Information processing; Language; Longitudinal Studies; Male; Medical research; Medicine, Experimental; Memory; Memory, Short-Term - drug effects; Memory, Short-Term - physiology; Neurosciences; Original Investigation; Pharmacology/Toxicology; Psychiatry; Reading; Regression analysis; Short term memory; Sleep; Social Class; Substance use
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/s00213-020-05596-8

Rationale There is a growing concern over excessive caffeine use and development of caffeine use disorder in children. Objectives This study aimed to identify the association between caffeine intake and cognitive functioning in children. Methods This study included 11,718 youths aged 9–10 years with cognitive and caffeine intake information that were extracted from the Adolescent Brain Cognitive Development (ABCD) study. The ABCD study is a longitudinal cohort study started in 2017 that aims to understand the relationships between substance use and neurocognition in youths living in the USA. Cognitive measures were obtained through the 7 core cognitive instruments from the NIH toolbox (vocabulary comprehension, reading decoding, inhibitory control, working memory, cognitive flexibility, processing speed, and episodic memory). Associations between caffeine intake and the seven cognitive functions were examined using multiple regression models. Results Our study revealed that caffeine intake negatively correlated with all the seven cognitive measures. After adjustment for age, gender, sleep, and socioeconomic status (SES), caffeine intake was still found to be negatively associated with most of the cognitive functions, such as vocabulary comprehension, working memory, cognitive flexibility, processing speed, and episodic memory, except reading decoding, and inhibitory control. Conclusions As beverages with caffeine are consumed frequently, controlling their intake may reduce a risk for nonoptimal cognitive development in children.