Joint Multi-modal Parcellation of the Human Striatum: Functions and Clinical Relevance

The human striatum is essential for both low- and high-level functions and has been implicated in the pathophysiology of various prevalent disorders, including Parkinson’s disease (PD) and schizophrenia (SCZ). It is known to consist of structurally and functionally divergent subdivisions. However, p...

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Bibliographic Details
Published in:Neuroscience bulletin 2020-10, Vol.36 (10), p.1123-1136
Main Authors: Liu, Xiaojin, Eickhoff, Simon B., Hoffstaedter, Felix, Genon, Sarah, Caspers, Svenja, Reetz, Kathrin, Dogan, Imis, Eickhoff, Claudia R., Chen, Ji, Caspers, Julian, Reuter, Niels, Mathys, Christian, Aleman, André, Jardri, Renaud, Riedl, Valentin, Sommer, Iris E., Patil, Kaustubh R.
Format: Article
Language:English
Subjects:
Anatomy
Anesthesiology
Biomedical and Life Sciences
Biomedicine
Connectivity-based parcellation
Convergent clusters
Human Physiology
Multi-modal
Neurology
Neurosciences
Neurosciences & behavior
Neurosciences & comportement
Original
Original Article
Pain Medicine
Parkinson’s disease
Schizophrenia
Sciences sociales & comportementales, psychologie
Social & behavioral sciences, psychology
Striatum
Voxel-based morphometry
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Summary:The human striatum is essential for both low- and high-level functions and has been implicated in the pathophysiology of various prevalent disorders, including Parkinson’s disease (PD) and schizophrenia (SCZ). It is known to consist of structurally and functionally divergent subdivisions. However, previous parcellations are based on a single neuroimaging modality, leaving the extent of the multi-modal organization of the striatum unknown. Here, we investigated the organization of the striatum across three modalities—resting-state functional connectivity, probabilistic diffusion tractography, and structural covariance—to provide a holistic convergent view of its structure and function. We found convergent clusters in the dorsal, dorsolateral, rostral, ventral, and caudal striatum. Functional characterization revealed the anterior striatum to be mainly associated with cognitive and emotional functions, while the caudal striatum was related to action execution. Interestingly, significant structural atrophy in the rostral and ventral striatum was common to both PD and SCZ, but atrophy in the dorsolateral striatum was specifically attributable to PD. Our study revealed a cross-modal convergent organization of the striatum, representing a fundamental topographical model that can be useful for investigating structural and functional variability in aging and in clinical conditions.
ISSN:1673-7067
1995-8218
1995-8218
DOI:10.1007/s12264-020-00543-1