4CPS-074 Impact of antibiotic prophylaxis guidelines in obstetric and gynaecology surgery: a retrospective multi-centre study

BackgroundAntibiotic prophylaxis in obstetrics and gynaecology (O and G) surgery is known to be effective in reducing postoperative infections, hospitalisation and costs. In 2008, local guidelines on antibiotic prophylaxis in surgery were published as a result of a multidisciplinary work group (incl...

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Bibliographic Details
Published in:European journal of hospital pharmacy. Science and practice 2018-03, Vol.25 (Suppl 1), p.A76-A76
Main Authors: Panciroli, C, Davies, SE Campbell, Dragonetti, MM, Luoni, A, Muserra, G, Patrizia, T, Bignamini, A, Minghetti, P
Format: Article
Language:English
Subjects:
Antibiotics
Disease prevention
Gynecology
Hysterectomy
Medical records
Section 4: Clinical pharmacy services
Surgery
Online Access:Get full text
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Summary:BackgroundAntibiotic prophylaxis in obstetrics and gynaecology (O and G) surgery is known to be effective in reducing postoperative infections, hospitalisation and costs. In 2008, local guidelines on antibiotic prophylaxis in surgery were published as a result of a multidisciplinary work group (including hospital pharmacists) which involved seven hospitals in the Lombardy Region. However, guidelines give general indications and the implementation into clinical practice is not always efficient.PurposeTo evaluate the impact of the introduction of local guidelines on antibiotic prophylaxis in elective O and G surgery 7 years after implementation.Material and methodsA multi-centre retrospective study was conducted involving three centres which had implemented the guideline in 2008 and was still in use. Medical records of patients undergoing elective surgical procedures in 2006 (pre-guideline) and 2015 (post-guideline) were reviewed by collecting data about patients, surgeries, postoperative infections and antibiotics. Data, collected from medical records, were transferred to a specifically designed database application in Filemaker Pro. Statistical analysis was performed by using SPSS and R. Comparisons were analysed using Chi square tests, multivariable logistic regression and analysis of variance. The effect estimate was reported in risk ratio (RR) and pooled using a random effects model.ResultsA total of 585 patients who underwent elective O and G procedures (caesarean section and vaginal hysterectomy) were analysed: 304 procedures for 2006 and 281 surgeries for 2015. ‘Adequate’ antibiotic prophylaxis substantially changed after guideline implementation (RR 1. 21; 95% CI: 1.14 to 1.29, p
ISSN:2047-9956
2047-9964
DOI:10.1136/ejhpharm-2018-eahpconf.165