Efficacy of tolterodine in children with overactive bladder

Tolterodine is an anticholinergic drug used for the treatment of overactive bladder. We evaluated the effects of tolterodine on clinical symptoms and compared its efficacy with that of oxybutynin in terms of bladder capacity, bladder wall thickness, and post-void residual volume in children with ove...

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Bibliographic Details
Published in:Turk Pediatri Arsivi 2020, Vol.55 (3), p.284-289
Main Authors: Koç, Başak, Canpolat, Nur, Adaletli, İbrahim, Sever, Lale, Emir, Haluk, Çalışkan, Salim
Format: Article
Language:English
Subjects:
Bladder
Drug therapy
Original / Özgün Araştırma
Pediatrics
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Summary:Tolterodine is an anticholinergic drug used for the treatment of overactive bladder. We evaluated the effects of tolterodine on clinical symptoms and compared its efficacy with that of oxybutynin in terms of bladder capacity, bladder wall thickness, and post-void residual volume in children with overactive bladder. Twenty-six patients who were treated with tolterodine for overactive bladder (20 girls, mean age 8.0±2.2 years) were evaluated retrospectively. Twenty patients with overactive bladder who had undergone oxybutynin treatment (15 girls, mean age 7.6±1.8 years) served as the control group. Dysfunctional voiding symptom scoring was used to evaluate the clinical response to tolterodine. To investigate the effect of treatment on the bladder, ultrasonographic data at baseline and the third month were compared with the oxybutynin group. The dysfunctional voiding symptom scores significantly decreased after the third month of tolterodine treatment (p
ISSN:1306-0015
2757-6256
1308-6278
DOI:10.14744/TurkPediatriArs.2020.98215