Targeting Eukaryotic Translation Initiation Factor 4E (eIF4E) in Cancer

Recent advances in understanding the role of eukaryotic translation initiator factor 4E (eIF4E) in tumorigenesis and cancer progression have generated significant interest in therapeutic agents that indirectly or directly target aberrant activation of eIF4E in cancer. Here, we address the general fu...

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Bibliographic Details
Published in:Clinical cancer research 2010-10, Vol.16 (20), p.4914-4920
Main Authors: HSIEH, Andrew C, RUGGERO, Davide
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Eukaryotic Initiation Factor-4E - genetics
Eukaryotic Initiation Factor-4E - metabolism
Humans
Medical sciences
Molecular Targeted Therapy - methods
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
Pharmacology. Drug treatments
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Summary:Recent advances in understanding the role of eukaryotic translation initiator factor 4E (eIF4E) in tumorigenesis and cancer progression have generated significant interest in therapeutic agents that indirectly or directly target aberrant activation of eIF4E in cancer. Here, we address the general function of eIF4E in translation initiation and cancer, present evidence supporting its role in cancer initiation and progression, and highlight emerging therapeutics that efficiently target hyperactivated eIF4E. In doing so, we also highlight the major differences between these therapeutics that may influence their mechanism of action.
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.ccr-10-0433