Dutch Oncology COVID-19 consortium: Outcome of COVID-19 in patients with cancer in a nationwide cohort study

• Published in: European journal of cancer (1990) 2020-12, Vol.141, p.171-184
• Main Authors: de Joode, Karlijn, Dumoulin, Daphne W., Tol, Jolien, Westgeest, Hans M., Beerepoot, Laurens V., van den Berkmortel, Franchette W.P.J., Mutsaers, Pim G.N.J., van Diemen, Nico G.J., Visser, Otto J., Oomen-de Hoop, Esther, Bloemendal, Haiko J., van Laarhoven, Hanneke W.M., Hendriks, Lizza E.L., Haanen, John B.A.G., de Vries, Elisabeth G.E., Dingemans, Anne-Marie C., van der Veldt, Astrid A.M., van Loenhout, C.J., van der Leest, C.H., Becker-Commissaris, A., Borgers, J.S.W., Terhegggen, F., van den Borne, B.E.E.M., van Warmerdam, L.J.C., van Leeuwen, L., van der Meer, F.S., Tiemessen, M.A., van Diepen, D.M., Klaver, Y., Hamberg, A.P., Libourel, E.J., Strobbe, L., Cloos, M., Geraedts, E.J., Drooger, J.C., Heller, R., de Groot, J.W.B., Stigt, J.A., Nuij, V.J.A.A., Pitz, C.C.M., Slingerland, M., Borm, F.J., Haberkorn, B.C.M., Westeinde, S.C. van 't, Aarts, M.J.B., van Putten, J.W.G., Youssef, M., Cirkel, G.A., Herder, G.J.M., van Rooijen, C.R., Citgez, E., Barlo, N.P., Scholtes, B.M.J., Koornstra, R.H.T., Claessens, N.J.M., Faber, L.M., Rikers, C.H., van de Wetering, R.A.W., Veurink, G.L., Bouter, B.W., Houtenbos, I., Bard, M.P.L., Herbschleb, K.H., Kastelijn, E.A., Brocken, P., Douma, G., Jalving, M., Hiltermann, T.J.N., Schuurbiers-Siebers, O.C.J., Suijkerbuijk, K.P.M., van Lindert, A.S.R., van de Wouw, A.J., van den Boogaart, V.E.M., Bakker, S.D., Looysen, E., Peerdeman, A.L., de Jong, W.K., Siemerink, E.J.M., Staal, A.J., Franken, B., van Geffen, W.H., Bootsma, G.P.
• Format: Article
• Language: English
• Subjects: Aged; Cancer; Cancer treatment; Cohort analysis; Cohort Studies; Consortia; Coronaviridae; Coronavirus; Coronaviruses; COVID-19; COVID-19 - epidemiology; Diagnosis; Fatalities; Female; Health risks; Health services; Hematology; Humans; Incidence; Lung cancer; Male; Malignancy; Medical diagnosis; Middle Aged; Neoplasms - epidemiology; Neoplasms - therapy; Neoplasms - virology; Netherlands - epidemiology; Oncology; Original Research; Pandemic; Pandemics; Physicians; Registries; Risk analysis; Risk Factors; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Subgroups; Treatment Outcome; Tumors; Vaccination; Viral diseases
• ISSN: 0959-8049; 1879-0852; 1879-0852
• DOI: 10.1016/j.ejca.2020.09.027

Patients with cancer might have an increased risk for severe outcome of coronavirus disease 2019 (COVID-19). To identify risk factors associated with a worse outcome of COVID-19, a nationwide registry was developed for patients with cancer and COVID-19. This observational cohort study has been designed as a quality of care registry and is executed by the Dutch Oncology COVID-19 Consortium (DOCC), a nationwide collaboration of oncology physicians in the Netherlands. A questionnaire has been developed to collect pseudonymised patient data on patients' characteristics, cancer diagnosis and treatment. All patients with COVID-19 and a cancer diagnosis or treatment in the past 5 years are eligible. Between March 27th and May 4th, 442 patients were registered. For this first analysis, 351 patients were included of whom 114 patients died. In multivariable analyses, age ≥65 years (p