Schwann cell interactions during the development of the peripheral nervous system

Schwann cells play a critical role in the development of the peripheral nervous system (PNS), establishing important relationships both with the extracellular milieu and other cell types, particularly neurons. In this review, we discuss various Schwann cell interactions integral to the proper establ...

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Bibliographic Details
Published in:Developmental neurobiology (Hoboken, N.J.) N.J.), 2021-07, Vol.81 (5), p.464-489
Main Authors: Wilson, Emma R., Della‐Flora Nunes, Gustavo, Weaver, Michael R., Frick, Luciana R., Feltri, M. Laura
Format: Article
Language:English
Subjects:
axon
Axons
Axons - metabolism
axo‐glial communication
Cell Communication
Cell interactions
Extracellular matrix
glia
myelin
Nervous system
Neuroglia - metabolism
peripheral nerve
Peripheral nerves
Peripheral Nervous System
Schwann cells
Schwann Cells - physiology
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Summary:Schwann cells play a critical role in the development of the peripheral nervous system (PNS), establishing important relationships both with the extracellular milieu and other cell types, particularly neurons. In this review, we discuss various Schwann cell interactions integral to the proper establishment, spatial arrangement, and function of the PNS. We include signals that cascade onto Schwann cells from axons and from the extracellular matrix, bidirectional signals that help to establish the axo‐glial relationship and how Schwann cells in turn support the axon. Further, we speculate on how Schwann cell interactions with other components of the developing PNS ultimately promote the complete construction of the peripheral nerve.
ISSN:1932-8451
1932-846X
DOI:10.1002/dneu.22744