MicroRNAs Responding to Space Radiation

High-energy and high-atom-number (HZE) space radiation poses an inevitable potential threat to astronauts on deep space exploration missions. Compared with low-LET radiation, high-energy and high-LET radiation in space is more efficient in inducing clustered DNA damage with more serious biological c...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-09, Vol.21 (18), p.6603
Main Authors: Yan, Yujie, Zhang, Kunlan, Zhou, Guangming, Hu, Wentao
Format: Article
Language:English
Subjects:
Astronauts
Carcinogenesis
Carcinogens
Cell cycle
Central nervous system
Cosmic Radiation - adverse effects
Cosmic rays
Cytoplasm
Deep space
Deoxyribonucleic acid
DNA
DNA damage
Exports
Extraterrestrial radiation
Gene expression
Genomes
Humans
Mammals
MicroRNAs
MicroRNAs - radiation effects
miRNA
Orbits
Proteins
Radiation damage
Review
Risk assessment
RNA polymerase
Space missions
Space stations
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Summary:High-energy and high-atom-number (HZE) space radiation poses an inevitable potential threat to astronauts on deep space exploration missions. Compared with low-LET radiation, high-energy and high-LET radiation in space is more efficient in inducing clustered DNA damage with more serious biological consequences, such as carcinogenesis, central nervous system injury and degenerative disease. Space radiation also causes epigenetic changes in addition to inducing damage at the DNA level. Considering the important roles of microRNAs in the regulation of biological responses of radiation, we systematically reviewed both expression profiling and functional studies relating to microRNAs responding to space radiation as well as to space compound environment. Finally, the directions for improvement of the research related to microRNAs responding to space radiation are proposed. A better understanding of the functions and underlying mechanisms of the microRNAs responding to space radiation is of significance to both space radiation risk assessment and therapy development for lesions caused by space radiation.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21186603