Separation and HPLC Characterization of Active Natural Steroids in a Standardized Extract from the Serratula coronata Herb with Antiseborrheic Dermatitis Activity

Phytoecdysteroids are natural compounds with therapeutic benefits in both humans and animals. The effectiveness of natural products with health potential is based on the activities and potencies of their active ingredients. In this study, dominant ecdysteroids-ajugasterone C, 20-hydroxyecdysone and...

Full description

Saved in:
Bibliographic Details
Published in:International journal of environmental research and public health 2020-09, Vol.17 (18), p.6453
Main Authors: Napierała, Marta, Nawrot, Joanna, Gornowicz-Porowska, Justyna, Florek, Ewa, Moroch, Arletta, Adamski, Zygmunt, Kroma, Anna, Miechowicz, Izabela, Nowak, Gerard
Format: Article
Language:English
Subjects:
Animals
Burning
Calibration
Chemical compounds
Chromatography, High Pressure Liquid - methods
Column chromatography
Dermatitis
Ecdysteroids
Herbs
High performance liquid chromatography
Humans
Itching
Liquid chromatography
Methods
Natural products
Pain
Pharmacology
Plant Extracts
Pruritus
Quality of Life
Quantitative analysis
Seborrheic dermatitis
Serratula
Skin
Statistical analysis
Steroid hormones
Steroids
Steroids - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phytoecdysteroids are natural compounds with therapeutic benefits in both humans and animals. The effectiveness of natural products with health potential is based on the activities and potencies of their active ingredients. In this study, dominant ecdysteroids-ajugasterone C, 20-hydroxyecdysone and polypodine B-from the ( ) herb were separated by column chromatography, identified by spectroscopic data and quantified by high-performance liquid chromatography with a diode array detector (HPLC-DAD). The obtained concentration of ecdysteroids (approximately 23%) in the herb extract enhances the possibility of their use in pharmaceutical and cosmetic products with high levels of phytoecdysteroids. Moreover, this study has shown a positive effect of ecdysteroids-containing cream on changes in quality of life and a beneficial effect in reducing the symptoms of seborrheic dermatitis. It has been demonstrated that the application of the cream with phytoecdysteroids resulted in a statistically significant alleviation of symptoms ( < 0.05), especially in terms of itching, pain or burning sensations in the affected areas in comparison to previous symptoms.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph17186453