Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) and the principle of primum non nocere

Perhaps with the intention of obtaining larger amounts of free-DNA, some groups are routinely postponing and establishing free-DNA collection in culture medium for Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) to day 6 for all blastocysts. A meta-analysis served as the basis...

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Bibliographic Details
Published in:JBRA assisted reproduction 2020, Vol.24 (4), p.391-391
Main Authors: Franco, Jr, Jose G, Dieamant, Felipe, Oliveira, Joao Batista A
Format: Article
Language:English
Subjects:
Biopsy
Births
Chromosomes
Embryos
Genetic testing
Laboratories
Meta-analysis
Reproductive technologies
Online Access:Get full text
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Summary:Perhaps with the intention of obtaining larger amounts of free-DNA, some groups are routinely postponing and establishing free-DNA collection in culture medium for Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) to day 6 for all blastocysts. A meta-analysis served as the basis for such decision, since statistically similar live birth rates were observed when the transfers of euploid blastocysts were performed on day 5 versus day 6 However, the euploidy analysis was conducted in only two studies However, after including the two more studies we performed a new meta-analysis that clearly showed the risks of losing live births with the decision of adopting the 6th day as the endpoint for gathering free-DNA. We would be losing 1.71x more live births.
ISSN:1518-0557
1517-5693
1518-0557
DOI:10.5935/1518-0557.20200075